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Ferulic acid and quinic acid, two phenolic compounds, are thought to have potent antioxidant and anti\u2010inflammatory properties. This study aimed to investigate the anti\u2010inflammatory and antioxidant effects of ferulic acid and quinic acid in rats with acetic acid (AA)\u2010induced ulcerative colitis. To this end, 64 Wistar rats were randomly divided into eight groups, each consisting of eight rats. AA was administered intrarectally to induce ulcerative colitis. Ferulic acid (20, 40, and 60\u2009mg\/kg), quinic acid (10, 30, 60, and 100\u2009mg\/kg), and dexamethasone (2\u2009mg\/kg) were received daily for five consecutive days. Then, the macroscopic and histopathological changes in the colon tissue were examined. Finally, the tissue levels of heme oxygenase 1 (HO1), nuclear factor erythroid 2\u2010related factor 2 (NRF2), and NAD(P)H quinone dehydrogenase 1 (NQO1) mRNA expression and pro\u2010inflammatory cytokine tumor necrosis factor alpha (TNF\u2010\u03b1) and interleukin\u20101 beta (IL\u20101\u03b2) were measured using the quantitative real\u2010time polymerase chain reaction (PCR) and enzyme\u2010linked immunosorbent assay (ELISA) methods, respectively. AA\u2010induced ulcerative colitis in rats was associated with edema and severe damage to the epithelium, infiltration of inflammatory cells, and the presence of ulcers in the colon tissue. The results showed that rats who were administered AA showed a decrease in the expression of HO\u20101, Nrf2, and NQO1 and increased protein levels of TNF\u2010\u03b1 and IL\u20101\u03b2 than the control group. Rats were administered ferulic acid, quinic acid and, dexamethasone significantly improved histopathological indices. The expression of HO\u20101, Nrf2, and NQO1 were upregulated by 60\u2009mg\/kg of ferulic acid, 60 and100 mg\/kg of quinic acid and, 2\u2009mg\/kg of dexamethasone treatment compared to the ulcerative colitis group. The protein levels of TNF\u2010\u03b1 and IL\u20101\u03b2 dose\u2010dependently decreased by ferulic acid and quinic acid treatment compared to the ulcerative colitis group. Ferulic acid and quinic acid effectively reduce inflammation and mucosal damage in rats with ulcerative colitis, especially when administered in high doses. The possible mechanism of anti\u2010inflammatory response by ferulic acid and quinic acid may involve the activating of the Nrf2\/HO\u20101 pathway.<\/jats:p>","DOI":"10.1002\/jbt.70169","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T05:31:26Z","timestamp":1739770286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Evaluation of Anti\u2010Inflammatory and Antioxidant Effects of Ferulic Acid and Quinic Acid on Acetic Acid\u2010Induced Ulcerative Colitis in Rats"],"prefix":"10.1002","volume":"39","author":[{"given":"Mahsa","family":"Ekhtiar","sequence":"first","affiliation":[{"name":"Medical Plants Research Center, Basic Health Sciences Institute Shahrekord University of Medical Sciences Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-8706","authenticated-orcid":false,"given":"Maryam","family":"Ghasemi\u2010Dehnoo","sequence":"additional","affiliation":[{"name":"Razi Herbal Medicines Research Center Lorestan University of Medical Sciences Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4469-8028","authenticated-orcid":false,"given":"Fatemeh","family":"Azadegan\u2010Dehkordi","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Basic Health Sciences Institute Shahrekord University of Medical Sciences Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-5513","authenticated-orcid":false,"given":"Nader","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Basic Health Sciences Institute Shahrekord University of Medical Sciences Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0205-x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-01074-z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110309"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1102942"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11582"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.02.016"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112073"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140320"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110263"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23208"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S133069"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2018.07.013"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2021.109512"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25133088"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59451-z"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf301807g"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.09.073"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060713"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2016.09.011"},{"issue":"4","key":"e_1_2_11_21_1","first-page":"1","article-title":"Pharmacological Insights Into the Multifaceted Biological Properties of Quinic Acid","volume":"40","author":"Benali T.","year":"2022","journal-title":"Biotechnology & Genetic Engineering Reviews"},{"key":"e_1_2_11_22_1","first-page":"482","article-title":"Ferulic Acid Ameliorates Tnbs\u2010Induced Ulcerative Colitis Through Modulation of Cytokines, Oxidative Stress, Inos, COX\u20102, and Apoptosis in Laboratory Rats","volume":"15","author":"Sadar S. 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