{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:04:35Z","timestamp":1780340675309,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A total of 12 new \u03b2\u2010halo alcohols and 12 new \u03b2\u2010halo thiol derivatives were synthesized. Natural alcohol compounds with known pharmacological properties were selected as starting substrates, aiming to synthesize compounds that have the potential to exhibit biological activity. The synthesis of \u03b2\u2010halo alcohol derivatives involved a two\u2010step process, while \u03b2\u2010halo thiol derivatives were carried out in three steps. Effective and inexpensive methods were used for all transformations. Yields for \u03b2\u2010halo alcohol derivatives ranged from 79% to 82%, and for \u03b2\u2010halo thiol derivatives from 66% to 71%. Their antibacterial properties against some gram (+) (\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    ) and gram (\u2212) (\n                    <jats:italic>Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa<\/jats:italic>\n                    ) strains were investigated. The antibacterial effects of 24 newly synthesized compounds were compared to commercially available antibiotics Chloramphenicol and Streptomycin.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70171","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T05:35:36Z","timestamp":1739770536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis and Investigation of Antibacterial Properties of Thymol, Carvacrol, Eugenol, and Perillyl Alcohol Based \u03b2\u2010Halo Alcohol and \u03b2\u2010Halo Thiol Compounds"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5326-1405","authenticated-orcid":false,"given":"Fatma","family":"\u00c7akmak","sequence":"first","affiliation":[{"name":"Chemistry Department Science Faculty, Sakarya University Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6893-8490","authenticated-orcid":false,"given":"Hande","family":"Toptan","sequence":"additional","affiliation":[{"name":"Sakarya University Training and Research Hospital, Medical Microbiology Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6909-316X","authenticated-orcid":false,"given":"Hayriye","family":"Genc Bilgicli","sequence":"additional","affiliation":[{"name":"Chemistry Department Science Faculty, Sakarya University Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8101-1104","authenticated-orcid":false,"given":"Mehmet","family":"K\u00f6ro\u011flu","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Department Medicine Faculty, Sakarya University Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-1432","authenticated-orcid":false,"given":"Mustafa","family":"Zengin","sequence":"additional","affiliation":[{"name":"Chemistry Department Science Faculty, Sakarya University Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(03)00211-X"},{"key":"e_1_2_8_3_1","volume-title":"Progress in Heterocyclic Chemistry","author":"Gribble G.","year":"2009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1071\/EN15002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(03)00207-8"},{"key":"e_1_2_8_6_1","first-page":"1","volume-title":"Progress in the Chemistry of Organic Natural Products","author":"Gribble G. 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