{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:50:02Z","timestamp":1783083002632,"version":"3.54.6"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Selenium (Se) is an essential trace element with well\u2010documented health benefits, including antioxidative, anti\u2010inflammatory, antiapoptotic, and anticarcinogenic properties. Selenium nanoparticles (nano\u2010Se) represent an advanced Se delivery system characterized by superior bioavailability and a reduced risk of Se\u2010related toxicity. This study investigates the protective efficacy of nano\u2010Se against cadmium chloride (CdCl\n                    <jats:sub>2<\/jats:sub>\n                    )\u2010induced infertility in adult male Wistar rats. The experimental design involved random allocation of the rats into nine groups: a healthy control group, a vehicle control group, three groups receiving nano\u2010Se alone at 0.05, 0.1, and 0.2\u2009mg\/kg b.w.\/day, a group exposed to CdCl\n                    <jats:sub>2<\/jats:sub>\n                    to induce infertility, and three CdCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2010exposed groups treated with nano\u2010Se. After 30 days of treatment, the animals were euthanized for biochemical and histopathological assessments. The findings revealed that nano\u2010Se administration ameliorated the detrimental effects of treatment CdCl\n                    <jats:sub>2<\/jats:sub>\n                    on serum testosterone levels. Additionally, nano\u2010Se significantly reduced malondialdehyde levels and enhanced the activity of antioxidant enzymes in testicular homogenates. Histological analyses further demonstrated that nano\u2010Se preserved the structural integrity of testicular tissue in the CdCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced fertility model. Nano\u2010Se modulated apoptotic pathways, as evidenced by the suppression of Bax expression and upregulation of Bcl\n                    <jats:sub>2<\/jats:sub>\n                    expression in testicular tissue. Furthermore, nano\u2010Se mitigated the overexpression of aquaporin\u20109 in CdCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2010exposed rats. Collectively, these results provide robust biochemical, histological, and biochemical evidence supporting the potential therapeutic utility of nano\u2010Se in mitigating testicular dysfunction.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70179","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T05:37:26Z","timestamp":1739770646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Nano Selenium on Cadmium Chloride\u2010Induced Infertility in Male Wistar Rats"],"prefix":"10.1002","volume":"39","author":[{"given":"Shahrbano","family":"Taromsari","sequence":"first","affiliation":[{"name":"Department of Biology, Science and Research Branch Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6673-5347","authenticated-orcid":false,"given":"Akram","family":"Eidi","sequence":"additional","affiliation":[{"name":"Department of Biology, Science and Research Branch Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2795-5371","authenticated-orcid":false,"given":"Pejman","family":"Mortazavi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch Islamic Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Modaresi","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Faculty of Biological Sciences Islamic Azad University of Khorasgan Branch Esfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1677-55382012000500002"},{"key":"e_1_2_11_3_1","unstructured":"P. J.Rowe F. H.Comhaire T. B.Hargreave andA. M.MahmoudWorld Health Organization.2000. apps.who.int\/iris\/handle\/10665\/42437."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.118-a528"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.01.028"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2012.10.060"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.09.004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233714566874"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2014.04.001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-015-0509-y"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-016-2839-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2016.11.001"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X18666200106152631"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13669"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.08.022"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2019.126435"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10590501.2015.1055163"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2014.3846"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1183487"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm221"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.30565\/medalanya.1483307"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-023-03622-2"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2004.05.001"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000178170"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-017-0980-8"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00527"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19042416"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2019.01.016"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21111517"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22768"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2018.12.017"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.006"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713526"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.20354"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053764635"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1016-8478(23)13017-2"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00128-010-9942-y"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.01.048"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483x(91)90030-5"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102209"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.34172\/apb.2020.023"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.22038\/IJBMS.2018.26023.6397"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.148"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3923\/ajava.2016.653.664"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-4337.2011.00156.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11050964"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13021790"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0742-8413(97)00063-7"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2022.108992"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112878"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00537"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.11.025"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2020.115274"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.160601"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2016.02.002"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61452-9"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.08.001"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-4274(01)00483-0"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.55.952"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1009273711068"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0300-483x(99)00115-8"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15070852"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.2013-097"},{"issue":"6","key":"e_1_2_11_64_1","first-page":"1799","article-title":"Tumor Suppressor p53 Is a Regulator of bcl\u20102 and Bax Gene Expression In Vitro and In Vivo","volume":"9","author":"Miyashita T.","year":"1994","journal-title":"Oncogene"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90509-o"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2017.07.027"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/19396368.2022.2033350"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.64.81"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.38.24737"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2004.tb02820.x"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2009.00998.x"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2009.01009.x"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.166039"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.70179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:27:29Z","timestamp":1780338449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.70179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/jbt.70179"],"URL":"https:\/\/doi.org\/10.1002\/jbt.70179","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70179"}}