{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:55:57Z","timestamp":1753869357626,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study focused on the role of the microRNA (miR)\u2010373\u20103p\/LATS2 axis in the prognosis and metastasis of thyroid cancer patients. miR\u2010373\u20103p and LATS2 expression were assessed in thyroid cancer tissues and cells. The relationship between miR\u2010373\u20103p and clinicopathological characteristics of patients with thyroid cancer and the impact of miR\u2010373\u20103p and LATS2 expression levels on the survival and prognosis of thyroid cancer patients were analyzed. The targeting relationship between miR\u2010373\u20103p and LATS2 was predicted and verified, and their impact on the malignant cell phenotype was assessed. Compared with adjacent normal tissues and normal human thyroid cells, miR\u2010373\u20103p was highly expressed, while LATS2 was expressed at low levels in thyroid cancer tissues and cells (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). miR\u2010373\u20103p expression was independent of age (<jats:italic>p<\/jats:italic>\u2009=\u20090.201) and gender (<jats:italic>p<\/jats:italic>\u2009=\u20090.516), and it was correlated with lymph node metastasis and TNM stage of thyroid cancer (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Moreover, high miR\u2010373\u20103p expression was associated with poor patient prognosis (<jats:italic>p<\/jats:italic>\u2009=\u20090.034). Interference with miR\u2010373\u20103p or overexpression of LATS2 repressed KMH\u20102 cell malignant phenotypes (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). miR\u2010373\u20103p targeted and suppressed LATS2 expression. Interference with miR\u2010373\u20103p blocked its inhibition on LATS2, thereby repressing thyroid cancer progression and metastasis.<\/jats:p>","DOI":"10.1002\/jbt.70181","type":"journal-article","created":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T19:25:41Z","timestamp":1740338741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanism of the microRNA\u2010373\u20103p\/LATS2 Axis in the Prognosis and Metastasis of Thyroid Cancer Patients"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2388-6936","authenticated-orcid":false,"given":"Yingchao","family":"Gu","sequence":"first","affiliation":[{"name":"Second Department of General Surgery Qionglai Medical Center Hospital Qionglai Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbing","family":"Liu","sequence":"additional","affiliation":[{"name":"Second Department of General Surgery Qionglai Medical Center Hospital Qionglai Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Shi","sequence":"additional","affiliation":[{"name":"Second Department of General Surgery Qionglai Medical Center Hospital Qionglai Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Pu","sequence":"additional","affiliation":[{"name":"Second Department of General Surgery Qionglai Medical Center Hospital Qionglai Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-55031-8_10"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2018.10.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2019-0780"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-020-00974-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2119"},{"issue":"7","key":"e_1_2_8_7_1","first-page":"427","article-title":"[MiR\u2010373\u20103p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells]","volume":"18","author":"Wu A.","year":"2015","journal-title":"Zhongguo Fei Ai Za Zhi = Chinese Journal of Lung Cancer"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25464"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6010926"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0357"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.19.13386"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.02.012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2017.17.e41"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1773"},{"issue":"6","key":"e_1_2_8_15_1","first-page":"3027","article-title":"miR\u2010214 Regulates Papillary Thyroid Carcinoma Cell Proliferation and Metastasis by Targeting PSMD10","volume":"42","author":"Liu F.","year":"2018","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0975-1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.05.027"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07515-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533033819852990"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.12.036"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00082"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2018.01.008"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2303-7"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-012-0570-5"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.2.591"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2016.3405"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1724600819827964"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12760"},{"issue":"9","key":"e_1_2_8_29_1","first-page":"569","article-title":"[Expression of Large Tumor Suppressor Homolog 2 Gene and Its Promotor Methylation in Oral Squamous Cell Carcinoma]","volume":"52","author":"Yue Z. 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