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This can increase oxidative stress which eventually damages the male reproductive system, disturbs the production of testosterone, alters semen quality and histological architecture, and increases testicular apoptosis. Dimethyl Fumarate (DMF) is an Nrf\u20102 activator that has been explored as possible protective agent in several preclinical studies, although its exact role in germ\u2010cell toxicity is still not well\u2010known. In the present study, an attempt has been made to elucidate the role of DMF in testicular toxicity in Sprague\u2010Dawley (SD) rats. Animals having fasting blood glucose &gt;250\u2009mg\/dl after treatment with Streptozotocin (STZ; 55\u2009mg\/kg, i.p) were considered diabetic. Three doses of DMF (12.5, 25, and 50\u2009mg\/kg) were administered to the diabetic animals for 4 consecutive weeks. The testicular damage was characterized by evaluating organ index, biochemical and histological parameters, sperm\u2010related indices, DNA strand breaks, and expression of different proteins. The results revealed that treatment with DMF ameliorated diabetes\u2010induced testicular damage by decreasing testicular oxidative stress and apoptosis, increasing testosterone production, and upregulating the expressions of Nrf\u20102, HO\u20101, IL\u201010, \u03b2\u2010Catenin, OCT\u20104, 3\u03b2\u2010HSD, Bcl\u20102 and downregulating NF\u2010\u03baB, Bax. The present finding suggests that DMF has a protective effect against diabetes\u2010induced testicular damage in SD rat.<\/jats:p>","DOI":"10.1002\/jbt.70209","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T19:30:45Z","timestamp":1743276645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dimethyl Fumarate Protects Diabetes\u2010Induced Testicular Toxicity in Rats: Investigations on Nrf\u20102\/HO\u20101 and \u03b2\u2010Catenin\/OCT\u20104 Signalling Pathways"],"prefix":"10.1002","volume":"39","author":[{"given":"Asutosh","family":"Pattnaik","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER), Facility for Risk Assessment and Intervention Studies S.A.S Nagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girija 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