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Interestingly, the COX enzyme possesses multiple structural similarities to the carbonic anhydrase enzyme. SLC\u20100111, a molecule known for its potent and selective inhibition of carbonic anhydrase, has not yet been studied for its potential effects on acute inflammation, proinflammatory cytokine levels, or oxidative stress parameters. Our study seeks to assess the binding affinity of SLC\u20100111 to the COX enzyme, as well as its possible anti\u2010inflammatory properties. We treated rats SLC\u20100111 at dosages of 50, 100, and 200\u2009mg\/kg for 3 days before generating inflammation with carrageenan (CAR). Following CAR delivery, paw thickness was evaluated at 4\u2010h intervals to assess inflammatory levels. Additionally, protein extravasation in paw tissue has been examined using Evans Blue (EB) dye. MDA and glutathione (GSH) levels in paw tissue were measured to assess oxidative stress. Carrageenan enhanced edema, protein extravasation, and proinflammatory cytokines TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, IL\u20104, and IL\u201013. SLC\u20100111 decreased all of these, except for IL\u20104. Similarly, the histological findings of our research indicated that SLC\u20100111 had an anti\u2010inflammatory effect at a dose of 200\u2009mg\/kg. However, SLC\u20100111 had no significant effect on MDA or GSH levels. These data represent that SLC\u20100111 may have anti\u2010inflammatory properties and could be used as a treatment for inflammation\u2010related disorders.<\/jats:p>","DOI":"10.1002\/jbt.70217","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:51:11Z","timestamp":1741755071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigating the Anti\u2010Inflammatory Potential of SLC\u20100111: A Carbonic Anhydrase Inhibitor Targeting Cyclooxygenase\u2010Mediated Inflammatory Pathways in a Carrageenan\u2010Induced Rat Model"],"prefix":"10.1002","volume":"39","author":[{"given":"Asl\u0131nur","family":"Do\u011fan","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy Ad\u0131yaman University Ad\u0131yaman 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