{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:04:04Z","timestamp":1788584644219,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Alzheimer's disease (AD) is the most common cause of dementia, a neurodegenerative disorder that progress overtime, which is best known for mood swings and loss of cognitive, behavioral and functional abilities. Quercetin is one of the most consumed flavonoids in the diet and has neuroprotective, anti\u2010inflammatory and antioxidant effects. The purpose of this study was to assess the potential neurotherapeutic effect of quercetin and compare it with donepezil. 40 Wister male rats were used and separated into two main groups: Group I: control group; Group II: AD group, which was divided into four subgroups: Group IIA: untreated AD\u2010rats; Group IIB: quercetin treated AD\u2010rats; Group IIC: donepezil treated AD\u2010rats and Group IID: combined group of quercetin and donepezil. Hydrated aluminum chloride (AlCl<jats:sub>3<\/jats:sub>.6H<jats:sub>2<\/jats:sub>O) solution (75\u2009mg\/kg\/day) was administered orally for 6 weeks to induce the AD\u2010like conditions. Morris water maze, behavior test, was used to monitor the cognitive function. Hippocampal tissues were excised for assessment of Alzheimer's parameters and blood samples were obtained for liver and kidney function assessment. According to the final findings, untreated rats presented significantly increased levels of amyloid \u03b2<jats:sub>1\u201042<\/jats:sub>; tau protein; malondialdehyde; nuclear factor kappa\u2010B; acetylcholinesterase activity, \u03b2\u2010site amyloid precursor protein cleaving enzyme 1 upregulation and miRNA\u2010124 downregulation. The best results of treatment were observed in the combination of donepezil and quercetin, as revealed by histopathological observations via H&amp;E and Congo red stains. This study led to the conclusion that quercetin, by targeting several pathogenic pathways, could be used as an adjuvant drug with donepezil for AD treatment.<\/jats:p>","DOI":"10.1002\/jbt.70290","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T07:00:37Z","timestamp":1746687637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the Neurotherapeutic Effect of Quercetin on Neuronal miR\u2010124 and \u03b2\u2010Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) in an Experimental Alzheimer's Disease Model"],"prefix":"10.1002","volume":"39","author":[{"given":"Aly S.","family":"Al\u2010Sawasany","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Medical Research Institute Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan M.","family":"Fayed","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical Research Institute Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bothaina F.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical Research Institute Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar S.","family":"Elblehi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7004-2260","authenticated-orcid":false,"given":"Nesma A.","family":"Ghazal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical Research Institute Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Fact Sheets of Dementia","author":"World Health Organization (WHO)","year":"2023"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043754"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13439"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210176"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091479"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-00961-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112681"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01555"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104515"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010120"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14100990"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-022-01308-6"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12112636"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59061084"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12638"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10010059"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041061"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.665031"},{"issue":"1","key":"e_1_2_11_20_1","first-page":"1","article-title":"Modeling Stages Mimic Alzheimer's Disease Induced by Different Doses of Aluminum in Rats: Focus on Progression of the Disease in Response to Time","volume":"1","author":"Ali A. 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