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Pasireotide (PAS), an FDA\u2010approved synthetic derivative of somatostatin, acts via binding to multiple somatostatin receptors, and it is commonly used in conditions unresponsive to first\u2010generation somatostatin analogs. Herein we explore the potential of PAS to protect against endothelial dysfunction induced by lipopolysaccharides (LPS). This is a bacterial toxin which causes inflammation and compromises endothelial barrier integrity. Endothelial cells were treated with PAS before LPS exposure to evaluate the corresponding effects on cell viability, inflammation, and barrier function. Since PAS suppressed LPS\u2010triggered endothelial injury, it is suggested that this compound could be repurposed for endothelium\u2010dependent disorder treatment.<\/jats:p>","DOI":"10.1002\/jbt.70306","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T11:37:18Z","timestamp":1747136238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pasireotide Exerts Anti\u2010Inflammatory Effects in the Endothelium"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4103-6260","authenticated-orcid":false,"given":"Saikat","family":"Fakir","sequence":"first","affiliation":[{"name":"School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy University of Louisiana Monroe Monroe Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madan","family":"Sigdel","sequence":"additional","affiliation":[{"name":"School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy University of Louisiana Monroe Monroe Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Matiur Rahman","family":"Sarker","sequence":"additional","affiliation":[{"name":"School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy University of Louisiana Monroe Monroe Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8366-5099","authenticated-orcid":false,"given":"Nektarios","family":"Barabutis","sequence":"additional","affiliation":[{"name":"School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy University of Louisiana Monroe Monroe Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1093691"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.179325"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.08.015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.54.76"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000182187"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008370.pub3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655298750026642"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00113-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-024-01480-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051852"},{"key":"e_1_2_10_12_1","first-page":"240","article-title":"Somatostatin Analogues and Multiple Receptors: Possible Physiological Roles","volume":"190","author":"Coy D. 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