{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:40:06Z","timestamp":1793497206254,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T00:00:00Z","timestamp":1747526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T00:00:00Z","timestamp":1747526400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, 16 novel quinazolin\u20104(3\n                    <jats:italic>H<\/jats:italic>\n                    )\u2010one derivatives were synthesized and evaluated for their antileishmanial activity against\n                    <jats:italic>Leishmania major<\/jats:italic>\n                    and\n                    <jats:italic>Leishmania donovani<\/jats:italic>\n                    . Among them, compounds\n                    <jats:bold>2<\/jats:bold>\n                    (4\u2010hydroxy substituted) and 9 (4\u2010morpholino substituted) exhibited the highest efficacy, with compound\n                    <jats:bold>2<\/jats:bold>\n                    showing IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 23.94\u2009\u03bcM for\n                    <jats:italic>L. major<\/jats:italic>\n                    and 90.80\u2009\u03bcM for\n                    <jats:italic>L. donovani<\/jats:italic>\n                    , while compound\n                    <jats:bold>9<\/jats:bold>\n                    demonstrated IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 23.05\u2009\u03bcM for\n                    <jats:italic>L. major<\/jats:italic>\n                    and 56.30\u2009\u03bcM for\n                    <jats:italic>L. donovani<\/jats:italic>\n                    . Miltefosine, the reference drug, showed IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 32.89\u2009\u03bcM for\n                    <jats:italic>L. major<\/jats:italic>\n                    , 4.78\u2009\u03bcM for\n                    <jats:italic>L. donovani<\/jats:italic>\n                    , and 7.53\u2009\u03bcM for HUVEC cells. Compound\n                    <jats:bold>2<\/jats:bold>\n                    showed superior selectivity (SI\u2009=\u200915.2 for\n                    <jats:italic>L. major<\/jats:italic>\n                    and 4.0 for\n                    <jats:italic>L. donovani<\/jats:italic>\n                    ) compared to miltefosine (SI\u2009=\u20094.4 for\n                    <jats:italic>L. major<\/jats:italic>\n                    and 0.6 for\n                    <jats:italic>L. donovani<\/jats:italic>\n                    ). Molecular docking studies identified phosphodiesterase B1 (PDEB1) as a key target, with compound\n                    <jats:bold>2<\/jats:bold>\n                    showing the strongest binding affinity. The docking score of compound\n                    <jats:bold>2<\/jats:bold>\n                    was calculated as \u201311.909\u2009kcal\/mol for PDEB1. ADME predictions indicated compound\n                    <jats:bold>2<\/jats:bold>\n                    's favorable pharmacokinetic profile, including good solubility, permeability, and adherence to Lipinski's Rule of Five. Overall, compound\n                    <jats:bold>2<\/jats:bold>\n                    exhibited the most promising therapeutic profile, highlighting its potential as a lead compound for antileishmanial drug development.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70309","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T02:48:59Z","timestamp":1747622939000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Design, Synthesis, and Evaluation of Novel Quinazolin\u20104(3\n                    <i>H<\/i>\n                    )\u2010One Derivatives: Anti\u2010Leishmanial Activity, Selectivity, and Molecular Docking Insights"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9480-3143","authenticated-orcid":false,"given":"Baycan","family":"Mor","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Sciences and Letters Kafkas University Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5532-8802","authenticated-orcid":false,"given":"Feyzi Sinan","family":"Tokal\u0131","sequence":"additional","affiliation":[{"name":"Department of Material and Material Processing Technologies, Kars Vocational School Kafkas University Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bar\u0131\u015f","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Life Sciences and Technologies Application and Research Center Kafkas University Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8333-035X","authenticated-orcid":false,"given":"Halil","family":"\u015eenol","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Bezmialem Vakif University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eeyma","family":"Aksu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Sciences and Letters Kafkas University Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neriman","family":"Mor","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology, Faculty of Medicine Kafkas University Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4274\/tdd.2880"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.2012.01034.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00104-14"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.21767\/1791-809X.1000519"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.14005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8081201"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14121592"},{"key":"e_1_2_9_9_1","first-page":"419","article-title":"Field Efficacy of Topical Nano\u2010Liposomal Amphotericin B (Sina Ampholeish\u00ae) Alone or in Combination With Glucantime\u00ae and Cryotherapy on Human Cutaneous Leishmaniasis","volume":"18","author":"Alizadeh Z.","year":"2023","journal-title":"Iranian Journal of Parasitology"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm5011397"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.13069"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8111803"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41182-024-00578-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjnpp.99060"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13568-022-01419-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10701.1"},{"key":"e_1_2_9_17_1","first-page":"2285","article-title":"The Cytotoxic Effect of ZnO Nps Against the Intracellular Amastigotes of Leishmania donovani In Vitro","volume":"58","author":"Salih M. 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