{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:00:03Z","timestamp":1785164403569,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002378","name":"Faculty of Veterinary Medicine, Cairo University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acetamiprid (ACP) is a novel neonicotinoid insecticide used frequently to eradicate insect pests. Resveratrol (RSV) is a polyphenol used as a potential antioxidant, anti\u2010inflammatory and antiapoptotic compound. The current research aimed to investigate the modulation of Jak\/Stat, p38 Mapk, and mTOR signaling pathways by RSV in ACP\u2010induced cardiotoxicity. Four equal groups of male rats (10 rats each) were treated daily for 90 days via oral intubation. Group 1 was the control; Group 2 received ACP (25\u2009mg\/kg b. wt); Group 3 received RSV (20\u2009mg\/kg b. wt); and Group 4 received both ACP and RSV. Gene expression and tissue proteins were analyzed in the heart while biochemical changes were estimated in serum. Histopathological and histochemical alterations of the cardiac tissues were also investigated. ACP administration showed elevations of mRNA expression of the inflammation\u2010related genes (Jak, Stat, NF\u2010\u03baB, p38 Mapk) and tissue proteins (mTOR and TNF\u2010\u03b1) in the myocardium. Significant serum high sensitivity C\u2010reactive protein (hs\u2010CRP) level and lactate dehydrogenase (LDH) activity were also recorded. Histopathology and immunohistochemistry showed myocardial infarction and inflammatory cell infiltration besides increased IL\u20106 protein expression. On the other hand, RSV treatment alleviated ACP\u2010induced cardiotoxic actions and modulated the expression levels of the inflammation\u2010related genes signaling pathways.<\/jats:p>","DOI":"10.1002\/jbt.70321","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T07:26:28Z","timestamp":1748330788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Resveratrol Mitigates Acetamiprid\u2010Induced Cardiotoxicity in Rats via Modulation of Jak\/Stat, p38 Mapk and mTOR Signaling Pathways"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5864-5563","authenticated-orcid":false,"given":"Rehab E.","family":"Abdelrahman","sequence":"first","affiliation":[{"name":"Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf M.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-8379","authenticated-orcid":false,"given":"Marwa A.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman I.","family":"Hassanen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.45.120403.095930"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-12314-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01820-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42690-019-00065-y"},{"key":"e_1_2_10_6_1","article-title":"Peer Review of the Pesticide Risk Assessment of the Active Substance Acetamiprid","volume":"14","author":"Food Safety Authority E","year":"2016","journal-title":"EFSA Journal"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65887-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.10.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-0331-5"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejceh.2016.254597"},{"key":"e_1_2_10_11_1","first-page":"44","article-title":"Oxidative Stress and Biochemical Changes Induced by Thiamethoxam and Acetamiprid Insecticides in Rats","volume":"5","author":"Keshta A.","year":"2016","journal-title":"World Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jflm.2022.102335"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/35081178"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2022.103982"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2015.05.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2024.114892"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.12.011"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2006.02.005"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061812"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TX00287H"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.08.087"},{"key":"e_1_2_10_22_1","first-page":"40","article-title":"Bancroft's Theory and Practice of Histological Techniques","author":"Suvarna S. 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