{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:27:21Z","timestamp":1790774841185,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetes is a disease characterized by insulin metabolism, and diabetic neuropathy (DN) develops as a result of prolonged hyperglycemia. Meteorin\u2010like protein (Metrnl), which has been found to regulate insulin resistance in conducted studies, is thought to be therapeutic for type\u20102 diabetes. This study was conducted to investigate the efficacy of Metrnl on In Vivo and In Vitro diabetic neuropathy model. In study, 40 normoglycemic male\n                    <jats:italic>Balb\u2010C<\/jats:italic>\n                    mice were divided into 4 groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910). Except for control, all groups received a single intraperitoneal (ip) injection of streptozotocin (STZ). After 72\u2009h, blood glucose level was measured and animals above 250\u2009mg\/dL were considered diabetic. 14\u2010day experiments were initiated 21 days after the onset of diabetes. Every day for 14 days, 0.9% isotonic sodium chloride was administered to DN group, and 2\u20134\u2009\u00b5g\/kg\/day ip Metrnl was administered to treatment groups, and nociceptive behavior tests were performed simultaneously. End of experiment, animals were decapitated, and pancreatic tissues were collected. Dorsal root ganglion (DRG) isolated from\n                    <jats:italic>Wistar Albino<\/jats:italic>\n                    rats aged 1\u20102 days were exposed to high glucose for 24\u2009, and the effect of Metrnl on cell viability and cellular pathway it utilizes were determined. It was observed that Metrnl injection increased the pain threshold (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), improved oxidative stress parameters (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), and restored histopathological damage of the pancreas (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) compared to the DN group. Furthermore, Metrnl was detected to increase cell viability by utilizing mitogen\u2010activated protein kinase pathway in DRG (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). These findings suggest that Metrnl has neuroprotective and analgesic efficacy and ameliorates oxidative damage and histopathologic status of pancreas.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70323","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:35:52Z","timestamp":1748586952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Effects of Meteorin\u2010Like Protein on Diabetic Neuropathy: In Vivo and In Vitro Model Studies"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1503-265X","authenticated-orcid":false,"given":"Furkan","family":"Yuksel","sequence":"first","affiliation":[{"name":"Department of Physiology Necmettin Erbakan University, Faculty of Veterinary Medicine  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3902-3210","authenticated-orcid":false,"given":"Asli","family":"Taslidere","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Inonu University, Faculty of Medicine  Malatya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5551-4880","authenticated-orcid":false,"given":"Mete","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Department of Biophysics F\u0131rat University, Faculty of Medicine  Elazig T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9038-1924","authenticated-orcid":false,"given":"Cigdem","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Health Care Services Inonu University, Vocational School of Health Services  Malatya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-1802","authenticated-orcid":false,"given":"Suat","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Physiology Inonu University, Faculty of Medicine  Malatya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3086167"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20080020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.294.3704"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0092-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci81156"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.11.2319"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53480-4.00029-1"},{"key":"e_1_2_8_10_1","first-page":"207","volume-title":"Classification of Chronic Pain Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms, Part III Pain Terms: A Current List with Definitions and Notes on Usage","author":"Merskey H.","year":"2002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.09.027"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12219"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.065"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0274"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0147-5"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12413"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-1027com"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.3.726"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.suppl_2.s97"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.931739"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-013-0278-z"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69020581.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.105997"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0886-7"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/750182"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.111"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-021-02197-w"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00284"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3791\/51608"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00697-X"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.3.497"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(84)05016-3"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.49484"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408500200"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.01.017"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.11.1932"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.11.3288"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123480"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290105"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15301"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.1.76"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32833c3026"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201206"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3425617"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199611000-00011"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12057"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)46030-5"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2022.100416"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2022.10.015"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07374-5"},{"issue":"3","key":"e_1_2_8_56_1","first-page":"393","article-title":"Clinical Effects of Electrical Stimulation Therapy on Lumbar Disc Herniation\u2010Induced Sciatica and Its Influence on Peripheral Ros Level","volume":"18","author":"Wang L.","year":"2018","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.01.026"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12107199"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4615"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.024"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06738.x"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2022.10.014"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101747"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001212"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.958033"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-013-9439-7"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1312"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0697-614"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.627147"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.70323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:21:52Z","timestamp":1771338112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.70323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":68,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/jbt.70323"],"URL":"https:\/\/doi.org\/10.1002\/jbt.70323","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"assertion":[{"value":"2024-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70323"}}