{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:50:08Z","timestamp":1791341408985,"version":"4.3.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We investigated the mechanism by which Iguratimod (IGU) inhibits arthritis. IGU can inhibit inflammatory responses in synovial macrophages, reducing the levels of inflammatory factors and NF\u2010\u03baB signaling. In animal experiments, IGU can suppress mouse arthritis damage, decrease the levels of inflammatory factors in tissues, improve mouse mobility, and inhibit NF\u2010\u03baB signaling. IGU can target NF\u2010\u03baB signaling to inhibit inflammatory responses in synovial macrophages, thereby alleviating arthritis and joint damage, which is an important mechanism for IGU in the treatment of arthritis.<\/jats:p>","DOI":"10.1002\/jbt.70329","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T13:09:12Z","timestamp":1749042552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Research on the Mechanism of Iguratimod in Inhibiting Arthritis Through NF\u2010\u03baB: An Experimental Study Based on Network Pharmacology"],"prefix":"10.1002","volume":"39","author":[{"given":"Lihua","family":"Meng","sequence":"first","affiliation":[{"name":"Rheumatology and Immunology Department Taiyuan Central Hospital  Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqing","family":"Duan","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department Taiyuan Central Hospital  Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maomao","family":"Fu","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department Taiyuan Central Hospital  Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department Taiyuan Central Hospital  Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Kang","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department Taiyuan Central Hospital  Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2237-3774","authenticated-orcid":false,"given":"Ming","family":"Yan","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department Taiyuan Central Hospital  Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department Taiyuan Central Hospital  Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehong","family":"Qiao","sequence":"additional","affiliation":[{"name":"Respiratory Department Taiyuan Central Hospital  Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.907750"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.10.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21741"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjpt.2020.08.004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00710-y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189887"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8868361"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-00923-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147645"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153305"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05148-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222944"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13623"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.06.014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070734"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1739-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/os.12423"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00312-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001651"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113513"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2022.102103"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14427"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2018.1493727"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1117489"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/20417314231164765"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041340"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S316756"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02512-z"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26571"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70329","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.70329","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:21:34Z","timestamp":1771338094000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.70329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/jbt.70329"],"URL":"https:\/\/doi.org\/10.1002\/jbt.70329","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70329"}}