{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:58:41Z","timestamp":1790891921746,"version":"4.1.0"},"reference-count":76,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acrylamide (ACR) is a toxic chemical with a high carcinogenic risk that is released as a result of heating or processing foods at high temperatures. Chrysin (CHR) is a flavonoid that is naturally found in foods such as honey and passionflower and stands out with its antioxidant, anticancer, and anti\u2010inflammatory properties. This study aims to determine the protective effects of CHR in ACR\u2010induced hepatotoxicity. ACR was administered orally at a dose of 38.27\u2009mg\/kg; CHR (25 or 50\u2009mg\/kg) was administered orally for ten days. Biochemical and molecular methods were used to investigate oxidative stress, inflammation, and apoptotic markers in liver tissue. Additionally, histological methods were used to determine the liver tissue's structural and functional characteristics and autophagy. CHR treatment alleviated ACR\u2010induced oxidative stress by increasing antioxidants (SOD, CAT, GPx, GSH) and reducing increased oxidant MDA. CHR reduced inflammatory activity by inactivating NF\u2010\u03baB and pro\u2010inflammatory cytokines. ACR\u2010induced increases in apoptotic Casp\u20103, Casp\u20106, Casp\u20109, and Bax were reduced by CHR, while the decreased level of antiapoptotic Bcl\u20102 was increased. It was also determined immunohistochemically that CHR inhibited autophagic Beclin\u20101 activity. CHR was effective in reducing ACR\u2010induced hepatotoxicity damage and may be an effective treatment option.<\/jats:p>","DOI":"10.1002\/jbt.70334","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T06:50:43Z","timestamp":1749451843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Protective Effects of Chrysin on Acrylamide\u2010Induced Hepatotoxicity: Insights Into Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histological Evaluation in Rats"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-4146","authenticated-orcid":false,"given":"Selman","family":"Gencer","sequence":"first","affiliation":[{"name":"Department of Internal Diseases, Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8457-9448","authenticated-orcid":false,"given":"Nurhan","family":"Akaras","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5573-4923","authenticated-orcid":false,"given":"Hasan","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6775-7858","authenticated-orcid":false,"given":"Cihan","family":"G\u00fcr","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Techniques, Vocational School of Health Services Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"\u0130lerit\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Horasan Vocational College Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8222-5515","authenticated-orcid":false,"given":"Sefa","family":"K\u00fc\u00e7\u00fckler","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biochemistry, Faculty of Veterinary Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-2479","authenticated-orcid":false,"given":"Fatih Mehmet","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09603123.2022.2123907"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11356-021-12422-X"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10937400600681430"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/JF0730486"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1588222"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.REPROTOX.2009.11.002"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11356-021-12775-3"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.29261\/pakvetj\/2024.153"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2022.0055"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ANTIOX11071347\/S1"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.22038\/IJBMS.2021.55009.12331"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FCT.2020.111190"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHYTOCHEM.2017.09.016"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871525717666190114145137"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2017.1337022"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/602360"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJPHAR.2009.12.031"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/SLCT.202303306"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BMCL.2015.10.052"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.34172\/bi.30269"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2021.112080"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.GENE.2023.147502"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11356-021-14049-4"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2016.12.065"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2019.1687510"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CBI.2022.110073"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.3.497"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(76)90747-6"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(68)90092-4"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90167-9"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/10520295.2024.2320626"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12291-018-0809-Z"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2020.574441\/BIBTEX"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS10092475"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1590\/ACB391124"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.LFS.2016.01.038"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12511"},{"key":"e_1_2_13_42_1","first-page":"13034","article-title":"Hyperbaric Oxygen Treatment Ameliorates Lung Injury in Paraquat Intoxicated Rats","volume":"8","author":"Akc\u0131lar R.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/JBT.23643"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.5152\/ABCR.2023.22123"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.46810\/tdfd.1299663"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.37989\/gumussagbil.1225539"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211054436"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/JBT.23751"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11033-021-06948-Z"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-11327-5"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEURO.2022.01.011"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2023.1161448\/BIBTEX"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FCT.2024.114791"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00210-019-01741-Z"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.22038\/IJBMS.2023.71905.15623"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/TOX.23900"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S261216"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CYTO.2024.156635"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11033-023-08286-8"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CBI.2022.110073"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11033-022-07928-7"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10735-018-9793-0"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11255-015-1169-8"},{"key":"e_1_2_13_64_1","first-page":"209","article-title":"Assessment of Expressions of Bcl\u2010XL, B\u2010FGF, Bmp\u20102, Caspase\u20103, PDGFR\u2010\u03b1, Smad1 and TGF\u2010\u03b21 Genes in a Rat Model of Lung Ischemia\/Reperfusion","volume":"19","author":"\u015eim\u015fek H.","year":"2016","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.14744\/ijmb.2023.07830"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CBI.2023.110410"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11356-023-29410-Y"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12011-023-04022-2"},{"key":"e_1_2_13_69_1","first-page":"53","article-title":"Naringin Protects Against Colistin\u2010Induced Sciatic Nerve Damage by Reducing Oxidative Stress, Apoptosis and Inflammation Damage","volume":"41","author":"Y\u0131lmaz S.","year":"2024","journal-title":"Journal of Experimental and Clinical Medicine"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.LFS.2021.120104"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11033-022-07395-0"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TIV.2021.105105"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12012-022-09751-9"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11033-023-08715-8"},{"key":"e_1_2_13_75_1","first-page":"245","article-title":"The Effect of Adropin on Lipid and Glucose Metabolism in Rats With Hyperlipidemia","volume":"19","author":"Akc\u0131lar R.","year":"2016","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/JBT.23604"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.LFS.2020.118382"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.70334","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:21:23Z","timestamp":1771338083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.70334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":76,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/jbt.70334"],"URL":"https:\/\/doi.org\/10.1002\/jbt.70334","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70334"}}