{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:52:33Z","timestamp":1772916753772,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Metaflumizone (MTF) is a pyrazoline sodium channel blocker (SBI) insecticide, and data on its toxicity are limited. Taurine (2\u2010aminoethanesulfonic acid) is a sulfur\u2010containing \u03b2\u2010amino acid that is naturally found in high concentrations in cells. In this study, we thoroughly evaluated the impact of taurine on MTF\u2010induced hepatonephrotoxicity in a rat model, focusing on oxidative stress, inflammatory responses, and programmed cell death. In the present study, MTF (500\u2009mg\/kg, orally) to induce hepatonephrotoxicity was delivered to male rats for 30 days, and taurine at different concentrations (50, 100, and 200\u2009mg\/kg, orally) was used for protective effect for the same period. Taurine treatment alleviated the elevated levels of AST, ALT, ALP, BUN, and creatinine caused by MTF. It further suppressed malate dehydrogenase levels and enhanced antioxidant defense by elevating SOD, GSH, and CAT levels. Additionally, taurine increased the mRNA expression levels of\n                    <jats:italic>Bcl\u20102<\/jats:italic>\n                    , which had been reduced due to oxidative stress, inflammatory, and apoptotic pathways, while suppressing the elevated gene expression levels of\n                    <jats:italic>NF\u03baB<\/jats:italic>\n                    ,\n                    <jats:italic>TNF\u2010\u03b1<\/jats:italic>\n                    ,\n                    <jats:italic>Bax<\/jats:italic>\n                    , and\n                    <jats:italic>Cas\u20103<\/jats:italic>\n                    . Furthermore, taurine regulated the altered protein expression levels of\n                    <jats:italic>Bcl\u20102<\/jats:italic>\n                    ,\n                    <jats:italic>Bax<\/jats:italic>\n                    , and\n                    <jats:italic>TNF\u2010\u03b1<\/jats:italic>\n                    induced by MTF. Microscopically, taurine also mitigated liver and kidney tissue damage caused by MTF. In conclusion, taurine significantly reduced MTF\u2010induced hepatonephrotoxicity by suppressing oxidative stress, inflammatory responses, and programmed cell death. These findings indicate that taurine has the potential to be a treatment option in the case of the prevention of liver and kidney damage caused by SBI.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70335","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T07:00:34Z","timestamp":1749452434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Taurine Mitigates Metaflumizone\u2010Induced Hepatonephrotoxicity in Rats by Inhibiting Oxidative Stress, Inflammation, and Apoptosis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4795-2266","authenticated-orcid":false,"given":"Hasan Huseyin","family":"Demirel","sequence":"first","affiliation":[{"name":"Bayat Vocational School Afyon Kocatepe University Afyonkarahisar T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1915-9797","authenticated-orcid":false,"given":"Sinan","family":"Ince","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology Afyon Kocatepe University Afyonkarahisar T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1744-1091","authenticated-orcid":false,"given":"Fahriye","family":"Zemheri\u2010Navruz","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Molecular Biology and Genetics Bart\u0131n University Bart\u0131n T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-7558","authenticated-orcid":false,"given":"Sevim Feyza","family":"Erdogmus","sequence":"additional","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy Afyonkarahisar Health Sciences University Afyonkarahisar T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-7158","authenticated-orcid":false,"given":"Nilay","family":"Isitez","sequence":"additional","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy Afyonkarahisar Health Sciences University Afyonkarahisar T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/CLEN.201800376"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.VETPAR.2007.08.031"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.VETPAR.2007.08.033"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2014.900180"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/MMR.2021.12242"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12970-021-00438-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/346237"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.YRTPH.2008.01.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4062\/BIOMOLTHER.2017.251"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/COSMETICS11010012"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2021.2021579"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/TOXRES\/TFAD005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/TOXRES\/TFAE120"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2017.09.141"},{"key":"e_1_2_10_16_1","first-page":"1","article-title":"FastPCR Software for PCR Primer and Probe Design and Repeat Search","volume":"3","author":"Kalendar R.","year":"2009","journal-title":"Genes, Genomes and Genomics"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/JCMM.17968"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.5958\/0973-970X.2019.00009.9"},{"issue":"1","key":"e_1_2_10_20_1","first-page":"180","article-title":"Indoxacarb Induces Liver Oxidative Stress in Swiss Albino Mice","volume":"2","author":"Mudaraddi T. 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