{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:10:24Z","timestamp":1771341024805,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of malignant plasma cells in bone marrow and remains largely incurable. The study aimed to investigate the role of miR\u2010155\u20105p in modulating malignant cellular behavior and tumorigenesis in MM. MiR\u2010155\u20105p expression in MM tissues and cells was measured by RT\u2010qPCR. In the context of miR\u2010155\u20105p overexpression, Transwell, wound healing, and CCK\u20108 assays were conducted to evaluate cell invasion, migration, and viability, respectively. Xenograft tumor models were established to explore the influence of miR\u2010155\u20105p and JARID2 on tumor growth in vivo. Gene interaction was analyzed using a luciferase reporter assay. Western blot analysis was carried out to quantify protein expression of JARID2 and components involved in the TGF\u03b2\/SMAD2 signaling pathway. Experimental results revealed that miR\u2010155\u20105p expression was significantly diminished in MM cells and tissue samples. Overexpressing miR\u2010155\u20105p not only suppressed MM cell viability, invasion, and migration but also restrained tumor growth. JARID2 was highly expressed in MM cells and identified as a direct target of miR\u2010155\u20105p. In MM tissues, miR\u2010155\u20105p expression was inversely correlated with JARID2 expression. Furthermore, JARID2 overexpression effectively reversed the inhibitory impacts of miR\u2010155\u20105p on cell malignancy and tumorigenesis. In addition, miR\u2010155\u20105p inactivated the TGF\u03b2\/SMAD2 pathway by negatively regulating JARID2 expression. In conclusion, miR\u2010155\u20105p inhibits MM cell malignancy and tumorigenesis by targeting JARID2 and inactivating the TGF\u03b2\/SMAD2 signaling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbt.70336","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T07:03:14Z","timestamp":1749452594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MiR\u2010155\u20105p Inhibits Multiple Myeloma Cell Malignancy and Tumorigenesis by Targeting JARID2 and Inactivating the TGF\u03b2\/SMAD2 Signaling"],"prefix":"10.1002","volume":"39","author":[{"given":"Yuan","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Bengbu Medical University Bengbu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The 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