{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:07:50Z","timestamp":1776215270994,"version":"3.50.1"},"reference-count":71,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Neuro\u2010inflammation is an important contributor in neurological disorders. Increased levels of cytokines and inflammatory markers are observed during brain damage. Fargesin is a naturally occurring compound classified as a lignan, a type of polyphenol frequently found in plants. It is particularly notable for its abundance in certain medicinal plants, such as Magnolia species, which are extensively used in traditional Asian medicine. Fargesis possess the potent antioxidant and anti\u2010inflammatory effect. We aim to investigate the inflammatory pathway\u2010mediated neuroprotective effect of fargesin against cerebral ischemia\/reperfusion (I\/R) injury in rats. Different doses of fargesin were administered to the rats before they performed 2\u2009h of right middle cerebral artery occlusion (MCAO) using the intraluminal filament technique, followed by 22\u2009h of reperfusion. Neurological score, brain edema, brain water content, evans blue leakage, sodium (Na\n                    <jats:sup>+<\/jats:sup>\n                    )\/calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    )\/potassium (K\n                    <jats:sup>+<\/jats:sup>\n                    ) ATPase, antioxidant, cytokines, matrix metalloproteinases (MMP) and inflammatory parameters were estimated. Treatment with fargesin significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) suppressed the neurological parameters alongwith reduction of brain water content, brain edema, evans blue leakage and infract volume. Fargesin treatment remarkably (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) suppressed the level of malonaldehyde (MDA) and boosted the level of superoxide dismutase (SOD), glutathione reductase (GR), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx) along with alteration of inflammatory cytokines such as tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin (IL)\u20101\u03b2, IL\u20106 and IL\u201010. Fargesin treatment significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) suppressed the level of inflammatory parameters inducible nitric oxide synthase (iNOS), cyclooxygenase\u20102 (COX\u20102), prostaglandin (PGE\n                    <jats:sub>2<\/jats:sub>\n                    ), Nuclear factor kappa factor (NF\u2010\u03baB), transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2) and MMP level such as MMP\u20102, MMP\u20103 and MMP\u20109 level. Fargesin treatment remarkably suppressed the mRNA expression of Toll\u2010like receptor 4 (TLR4), syndecan, colony\u2010stimulating factor (CSF), aquaporin\u20101, REX1 and organic cation transporter 3 (OCT3). Fargesin demonstrated a brain protective effect against cerebral ischemia reperfusion through a lowering of inflammatory markers.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70354","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T02:32:14Z","timestamp":1750732334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fargesin Exerts Neuroprotective Effect Against Cerebral Ischemia\/Reperfusion Injury in Rats via Alteration of NF\u2010\u03baB Signaling Pathway"],"prefix":"10.1002","volume":"39","author":[{"given":"Ming","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Critical Medicine The People's Hospital of Renshou County Renshou, Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine The People's Hospital of Renshou County Renshou, Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine The People's Hospital of Renshou County Renshou, Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine The People's Hospital of Renshou County Renshou, Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JingFang","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine The People's Hospital of Renshou County Renshou, Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine The People's Hospital of Renshou County Renshou, Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XueGang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine The People's Hospital of Renshou County Renshou, Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShuangXia","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine The People's Hospital of Renshou County Renshou, Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4384-3240","authenticated-orcid":false,"given":"Gang","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine The People's Hospital of Renshou County Renshou, Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.934256"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00298"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.09.025"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.139462"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5370214"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113696"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111303"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2020.1821518"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.947978"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.ess21037"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.128220"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189211"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01303-z"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1911"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2017.02.006"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2018.0249"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1691\/ph.2022.1227"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02512-z"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23061380"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.03.004"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.10.008"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.950457"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1537363"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.11.001"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.07.020"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.4021\/jocmr2010.02.263w"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v3.i6.186"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00371"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.47697"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2018.08.098"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.750731"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(03)00031-5"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S344240"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559325820917288"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S139362"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14011932"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.607412"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.57.3.368"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118392"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7205"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.770329"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.05.027"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867322666150209154036"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-016-0483-x"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049701"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199705000-00001"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568007043337247"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401781"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27103194"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199812)41:12<2165::AID-ART11>3.0.CO;2-O"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00443-w"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020445"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.4196\/KJPP.2021.25.2.97"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14105"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1999.16.1023"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1151-3"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.633610"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.07.007"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2018.451.459"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-9465-2_5"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105238"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191150"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01757-9"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1780153"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-020-00714-6"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1447060"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/124614"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00227"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.754141"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010055"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20916"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.70354","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:43:17Z","timestamp":1771335797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.70354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,23]]},"references-count":71,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/jbt.70354"],"URL":"https:\/\/doi.org\/10.1002\/jbt.70354","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,23]]},"assertion":[{"value":"2024-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70354"}}