{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:08:53Z","timestamp":1791828533021,"version":"4.3.4"},"reference-count":141,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This in\u2010depth review examines the complex interactions between miRNAs and Celiac disease (CD) across various biological aspects. The discussion begins with an in\u2010depth examination of miRNAs' biogenesis and functional pathways, highlighting their critical regulatory roles in cellular processes. The exploration extends to CD pathogenesis, elucidating how miRNAs contribute to the aberrant immune response against gluten in the small intestine. We navigate miRNAs' regulatory influence on intestinal development and innate and adaptive immunity, providing a panoramic view of their impact on CD etiology. Some miRNAs, such as miR\u2010449a, miR\u2010192\u20105p, miR\u201031\u20105p, miR\u201017, miR\u201030a, miR\u2010638, miR\u2010192, miR\u2010194\u20105p, and miR\u2010197, are dysregulated in CD and are involved in various pathways, including Notch1, tight junctions, and other pathogenetic pathways. The clinical importance of miRNAs takes center stage, unveiling their potential as diagnostic and prognostic markers and reshaping CD management. Investigating miRNA\u2010based therapeutic interventions opens avenues for precision medicine in modulating CD's immune dysregulation. With clinical advancements such as locked nucleic acid\u2010modified antimiRs that target miR\u2010122 for the treatment of hepatitis C and miR\u201034a mimics for hepatocellular carcinoma, microRNAs are promising therapeutic targets. Additionally, novel delivery systems such as lipid nanoparticles and tissue\u2010specific conjugates address the crucial challenges of targeted miRNA modulation. Extracellular vesicle miRNAs add a layer of complexity, acting as mediators in CD's systemic effects. Finally, we outline future perspectives, envisioning how the evolving landscape of miRNA research can propel advancements in understanding, diagnosis, and treatment, marking this review as a cornerstone for researchers and clinicians in the dynamic field of miRNAs and CD.<\/jats:p>","DOI":"10.1002\/jbt.70361","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T02:31:31Z","timestamp":1750732291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["miRNAs as Biomarkers and Therapeutic Targets in Celiac Disease: Current Advances and Future Directions"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5546-9020","authenticated-orcid":false,"given":"Reda M.","family":"Mansour","sequence":"first","affiliation":[{"name":"Zoology and Entomology Department Faculty of Science Helwan University Helwan Egypt"},{"name":"Molecular Biology and Biotechnology Department School of Biotechnology Badr University in Cairo Badr Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-7096","authenticated-orcid":false,"given":"Ahmed S.","family":"Doghish","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy Badr University in Cairo (BUC) Badr Egypt"},{"name":"Biochemistry and Molecular Biology Department Faculty of Pharmacy (Boys) Al\u2010Azhar University Nasr Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Amr","family":"Raouf","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department Faculty of Pharmacy Badr University in Cairo (BUC) Badr Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrhman M.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Badr University in Cairo (BUC) Badr Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aml","family":"Ghanem","sequence":"additional","affiliation":[{"name":"School of Biotechnology Badr University in Cairo (BUC) Badr Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed H. 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