{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:50:44Z","timestamp":1789667444098,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hypertension\u2010induced renal injury arises from endothelial dysfunction and elevated glomerular permeability. Telmisartan, an Angiotensin II (Ang II) receptor blocker (ARB), is commonly used to treat hypertension and is known for its long\u2010lasting effects, as well as its antioxidant and anti\u2010inflammatory properties. However, the effects of Telmisartan on glomerular permeability are less well\u2010documented. This study investigates the protective effects of Telmisartan (TEL), an Ang II receptor blocker, on hypertension\u2010induced kidney damage. Using a mouse model of Angiotensin II\/high salt (ANG\/HS)\u2010induced hypertension, TEL treatment significantly reduced mean arterial pressure, alleviated renal fibrosis, and improved kidney function, as indicated by lower urinary albumin and serum creatinine levels. TEL also suppressed oxidative stress and reduced the expression of inflammatory markers interleukin\u20106 (IL\u20106) and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) in renal tissues. Furthermore, TEL restored the expression of the tight junction protein zonula occludens\u20101 (ZO\u20101) in the glomeruli, which was downregulated in ANG\/HS\u2010treated mice.\n                    <jats:italic>In vitro<\/jats:italic>\n                    studies on human renal glomerular endothelial cells (HrGECs) confirmed that TEL reduced endothelial monolayer permeability and restored ZO\u20101 expression, effects that were mediated by Kr\u00fcppel\u2010like factor 4 (KLF4). These findings suggest that TEL mitigates glomerular endothelial permeability and kidney damage through antioxidant, anti\u2010inflammatory, and KLF4\u2010dependent mechanisms, offering potential therapeutic benefits for hypertension\u2010related renal damage.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70377","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T08:26:37Z","timestamp":1751617597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Telmisartan Ameliorates Hypertension\u2010Induced Kidney Damage by Restoring Glomerular Endothelial Barrier Function"],"prefix":"10.1002","volume":"39","author":[{"given":"Qiongqiong","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Blood Purification Center the First Affiliated Hospital of Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1059-608X","authenticated-orcid":false,"given":"Junxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Blood Purification Center the First Affiliated Hospital of Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00115.2015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113816128266582231031111516"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113146"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2013.55"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113146"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-025-04070-x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-01878-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00489-1"},{"issue":"11","key":"e_1_2_9_10_1","first-page":"597","article-title":"[Microalbuminuria and Arterial Hypertension]","volume":"28","author":"Hornych A.","year":"1999","journal-title":"Presse Medicale (Paris, France: 1983)"},{"issue":"5","key":"e_1_2_9_11_1","first-page":"4138","article-title":"Azilsartan Improves Urinary Albumin Excretion in Hypertension Mice","volume":"16","author":"Cao J.","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.078"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1278"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.177626"},{"issue":"14","key":"e_1_2_9_15_1","first-page":"2621","article-title":"Vascular Endothelial Growth Factor Increases GEnC Permeability by Affecting the Distributions of Occludin, ZO\u20101 and Tight Juction Assembly","volume":"19","author":"Zhang L.","year":"2015","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-024-01471-3"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116169"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.06.023"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/159874"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-024-01410-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331704"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170131"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00012-1"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2014.05.001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12134-8"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01780-x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00216"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00096.2006"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00253.2022"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2024.112309"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-85992-2"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-01843-5"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00052.2005"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.01.168"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006101084"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00862.2007"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015121324"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29277-6"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20412"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00098.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.111.3.1255"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1998.274.1.F1"},{"issue":"10","key":"e_1_2_9_43_1","first-page":"18751","article-title":"Effect of Dexmedetomidine on Rats With Renal Ischemia\u2010Reperfusion Injury and the Expression of Tight Junction Protein in Kidney","volume":"8","author":"Liu Y. E.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201800008"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO01319H"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24523"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-024-01238-3"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24523"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48852-7"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.416"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98214"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.70377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:43:14Z","timestamp":1771335794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.70377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/jbt.70377"],"URL":"https:\/\/doi.org\/10.1002\/jbt.70377","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70377"}}