{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:29:23Z","timestamp":1790530163470,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>CircRNAs can be applied as tumor biomarkers and potential therapeutic targets. Nevertheless, the function of circ_PSD3 in papillary thyroid carcinoma (PTC) has not been thoroughly explored. The current project attempts to analyze it. RT\u2010qPCR was adopted for measuring the expression of circ_PSD3, HMGB3, miR\u2010145\u20105p as well as miR\u2010338\u20103p in PTC tissues and cells. Through performing cell counting kit\u20108 and transwell experiments, the biological effects of circ_PSD3, HMGB3, miR\u2010145\u20105p and miR\u2010338\u20103p on PTC cells were detected. Besides, a dual\u2010luciferase reporter gene was employed to identify the underlying mechanism of circ_PSD3. The Western blot analysis assay was utilized to assess the expression levels of molecular marker proteins associated with epithelial\u2010mesenchymal transition. According to the results, the expressions of circ_PSD3 and HMGB3 showed obvious upregulation in PTC tissues, whereas knockdown of circ_PSD3 or HMGB3 notably hindered cell proliferation, migration as well as invasion in PTC. Mechanistically, it could be discovered that miR\u2010145\u20105p and miR\u2010338\u20103p served as the targets of circ_PSD3, and HMGB3 was a target of miR\u2010145\u20105p and miR\u2010338\u20103p. Moreover, miR\u2010145\u20105p and miR\u2010338\u20103p were discovered to play the role of tumor suppressors in PTC. More importantly, the findings showed that cell proliferation, migration, invasion together with EMT processes were attenuated by circ_PSD3 knockdown, but partially counteracted by miR\u2010338\u20103p (miR\u2010145\u20105p) inhibitor or HMGB3 overexpression. Based on the obtained data, circ_PSD3 promotes PTC cell proliferation, migration, invasion and EMT by regulating the miR\u2010145\u20105p\/miR\u2010338\u20103p\/HMGB3 axis. The current work revealed the mechanism of action of circ_PSD3 in PTC and may play the role of a new medical target for PTC.<\/jats:p>","DOI":"10.1002\/jbt.70402","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T07:29:22Z","timestamp":1753255762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Circ_PSD3 Stimulates Cell Proliferation, Migration, Invasion and Epithelial to Mesenchymal Transition (EMT) in Papillary Thyroid Carcinoma via the Regulation of miR\u2010145\u20105p\/miR\u2010338\u20103p\/HMGB3 Axis"],"prefix":"10.1002","volume":"39","author":[{"given":"Pengli","family":"Han","sequence":"first","affiliation":[{"name":"Department of translational Medical Center Zhengzhou Central Hospital Affiliated to Zhengzhou University Zhengzhou 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