{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T19:42:52Z","timestamp":1776022972368,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Circular RNAs (circRNAs), a class of endogenous noncoding RNAs, play crucial roles in various physiological and pathological processes. This study aimed to investigate the role and underlying mechanisms of circRNA_26782 in spinal neurons. We analyzed the differential expression profiles of circRNAs in a rat model of spinal cord injury and identified circRNA_26782 as being downregulated. Fluorescence in situ hybridization assay demonstrated that circRNA_26782 is primarily situated in the neuronal cytoplasm. Knockdown of circRNA_26782 remarkably increased axonal length. RNA sequencing identified miR\u201019b\u20102\u20105p as a key miRNA upregulated following circRNA_26782 depletion. Axonal growth was significantly enhanced by either overexpressing miR\u201019b\u20102\u20105p or downregulating its target gene, Rab1b. Co\u2010silencing of circRNA_26782 and miR\u201019b\u20102\u20105p indicated that miR\u201019b\u20102\u20105p inhibition rescued the increased axon length induced by circRNA_26782 knockdown. Additionally, the autophagy pathway was inhibited upon circRNA_26782 knockdown, miR\u201019b\u20102\u20105p overexpression, or Rab1b downregulation in rat spinal neurons. This study is the first to demonstrate that circRNA_26782 promotes axonal growth by inhibiting the autophagy pathway through the miR\u201019b\u20102\u20105p\/Rab1b axis. These findings offer new insights into the molecular mechanisms regulating axonal growth, and potentially informing therapeutic strategies for spinal cord injury.<\/jats:p>","DOI":"10.1002\/jbt.70404","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T07:25:17Z","timestamp":1753255517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CircRNA_26782 Regulates Axonal Growth via Inhibiting the Autophagy Pathway in a Rat Model of Spinal Cord Injury"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5642-9995","authenticated-orcid":false,"given":"Xiaowei","family":"Qian","sequence":"first","affiliation":[{"name":"Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Co\u2010innovation Center of Neuroregeneration Nantong University Nantong 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