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Concerns have been raised in the field of chemical processing since hazardous and combustible solvents are utilized in enormous quantities daily. All living organisms are prone to exposure to hazardous solvents, which leads to the destruction of most vital organs and the deterioration of health. Large volumes of organic and aromatic solvents, such as benzene, toluene, and chlorinated solvents, as well as solvents like acetone, Dimethyl sulfoxide (DMSO), and Dimethyl formamide (DMF), are still used despite their contribution to environmental deterioration, ecological degradation, and detrimental health effects. The target of the field of \u201cgreen chemistry,\u201d which combines chemistry and chemical engineering, is to create products and procedures that use as little or no harmful materials as possible. Environmentally conscious concerns should be incorporated into the definition of the performance of products, feedstocks, and manufacturing processes to embrace the principles of green chemistry and green engineering. Sustainable chemistry, sometimes known as \u201cgreen chemistry,\u201d is the design, production, and application of safe, effective, efficient, and ecologically friendly chemical processes and products. To create green imperishable chemical products, this article illuminates the usage of safer chemicals such as water, supercritical CO\n                    <jats:sub>2,<\/jats:sub>\n                    polyethylene glycol, fluorous biphasic solvent, and ionic liquids. Examples of chemical reactions in safer solvents are accounted for in this article. 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