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The Wiskott\u2013Aldrich syndrome protein (WASP) family members significantly contribute to the regulation of actin cytoskeleton (AC) dynamics and cancer cell invasion and metastasis. Recent research has demonstrated that WASP and its homolog, the WASP family verprolin\u2010homologous protein (WAVE), function as a master regulator and a key scaffolding protein, bringing together the various components of metastatic signaling complexes, thereby facilitating the development of solid tumors. The occurrence and progression of aggressive hematologic neoplasia can also be affected by WASP mutations. Recent research reveals that WASPs and WAVEs can act as either suppressors or enhancers of cancer malignancy, depending on the clinical or preclinical scenarios. WASPs and WAVEs' dual roles in cancer possibly originate from their diverse involvement in cell biology, which might be a novel approach to developing anticancer drugs. Therefore, this review aims to examine the role of the WASP family in cancer progression by focusing on their signaling network and molecular processes in both solid and hematological malignancies.<\/jats:p>","DOI":"10.1002\/jbt.70435","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T06:22:56Z","timestamp":1755584576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Role of the Wiskott\u2013Aldrich Syndrome Protein Family in Cancer Development, Invasion, and Metastasis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3563-4438","authenticated-orcid":false,"given":"Yi","family":"Tian","sequence":"first","affiliation":[{"name":"Microbiology and Immunology Department Cangzhou Medical College Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention National Institute for Viral Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandi","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention National Institute for Viral Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Jin","sequence":"additional","affiliation":[{"name":"Chinese Center for Disease Control and Prevention National Institute for Viral Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00320-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-01195-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13081882"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.01.086"},{"key":"e_1_2_11_6_1","first-page":"99","article-title":"Role of the Wasp and Wave Family Proteins in Breast Cancer Invasion and Metastasis","volume":"7","author":"Frugtniet B.","year":"2015","journal-title":"Breast cancer (Dove Medical Press)"},{"key":"e_1_2_11_7_1","article-title":"Wasp Facilitates Tumor Mechanosensitivity in T Lymphocytes","volume":"4","author":"Mandal S.","year":"2023","journal-title":"bioRxiv"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.674572"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2022.151244"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/TACG.S213920"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2022.2074400"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-017-0453-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31220-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-6-226"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-89911-6.00016-9"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000033158"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00859"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01004-1"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.10.024"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.199570"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20160176"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9091217"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/781523"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2019.04.007"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-24-811"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V55.2.243.243"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02409.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706881104"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2024.110204"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.09.003"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.06.025"},{"key":"e_1_2_11_32_1","first-page":"340","article-title":"Next Generation Sequencing Reveals Skewing of the T and B Cell Receptor Repertoires in Patients With Wiskott\u2010Aldrich Syndrome","volume":"5","author":"O'connell A. 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