{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:03:31Z","timestamp":1790017411840,"version":"4.0.1"},"reference-count":137,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Alzheimer's disease (AD) is a long\u2010term, progressive, degenerative disorder. One of the most important pathological characteristics of AD is the deposition of \u03b2\u2010amyliod (A\u03b2) peptide, which initiates a spectrum of cerebral neuroinflammation. Vascular changes also play an important role in the pathophysiology of the disease. Cytokines, secreted by immune cells, can facilitate cell\u2010to\u2010cell signaling and influence the functions of the central nervous system (CNS). These important mediators of the immune system, which are known to orchestrate various molecular and cellular mechanisms in both physiological and pathological situations, can be upregulated or downregulated, leading to a complex crosstalk with numerous receptors mediating pro\u2010inflammatory and\/or anti\u2010inflammatory actions. In particular, the interleukin (IL)\u20101 family of cytokines has been implicated to significantly correlate with AD pathogenesis among other cytokines in the CNS. The IL\u20101 family of cytokines is essential in both the innate and adaptive immune responses. This pleiotropic family of cytokines includes IL\u20101\u03b1, IL\u20101\u03b2, IL\u20101 receptor antagonist (RA), IL\u201018, IL\u201033, IL\u201036\u03b1, IL\u201036\u03b2, IL\u201036\u03b3, IL\u201036RA, IL\u201037, and IL\u201038. Recent studies have demonstrated that the upregulation of pro\u2010inflammatory cytokines, such as IL\u20101\u03b1 and IL\u20101\u03b2, or the downregulation of anti\u2010inflammatory mediators, exerts multifaceted influences on both neurodegeneration and neuroprotection. The lack of effective treatment for AD necessitates the search for new drugs that target several processes in the disease's pathology. This review aims to give a comprehensive overview of the emerging roles of the IL\u20101 family of cytokines in AD pathology and to explain their perspectives on introducing novel strategies for effective therapeutic\/neuropsychiatric management of AD in clinical settings by discussing both the pathogenic and protective roles of these cytokines.<\/jats:p>","DOI":"10.1002\/jbt.70460","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T07:01:37Z","timestamp":1755759697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Crosstalk Between Protective and Detrimental Interleukin (IL)\u20101 Family of Cytokines in Alzheimer's Disease"],"prefix":"10.1002","volume":"39","author":[{"given":"Tingting","family":"Liu","sequence":"first","affiliation":[{"name":"Engineering College Guangzhou College of Technology and Business Foshan City Guangdong Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3702-7805","authenticated-orcid":false,"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Ganzhou People's Hospital Ganzhou Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-016-3430-y"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-23226-5_8"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.07.021"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9050524"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201709069"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1468561"},{"key":"e_1_2_12_11_1","first-page":"136","article-title":"Role of Pro\u2010Inflammatory Cytokines Released From Microglia in Alzheimer's Disease","volume":"3","author":"Wang W. Y.","year":"2015","journal-title":"Annals of Translational Medicine"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8657-1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1110-973"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12616"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210794519147"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604032113"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215125"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c05693"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0957154X9100200506"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-022-00338-8"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-022-01721-1"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3880"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0315-0"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155635"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.125"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102504"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.796867"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1760623"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/480739"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12896"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.12.019"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040319"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00463a009"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12621"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.06.003"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-016-0855-0"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115884109"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.12.072"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2013.10.001"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12606"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217996110"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.910983"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.176"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-019-0101-5"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112306"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3800"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2011.10.001"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.872155"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP090780"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2021.577529"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-101011-155745"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.05.017"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.503"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036893"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(07)63020-9"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12341"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.012"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100620"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909586107"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000040248"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110024"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31450"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4361-12.2013"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.05127.x"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-019-00544-4"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00395"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.10.001"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.06.006"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210794519147"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-199"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.09.012"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-199"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.07.009"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00405-5"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.04.003"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801802115"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134674"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.1.73"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S314638"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.06.006"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genrep.2020.100823"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-94"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297914120049"},{"key":"e_1_2_12_84_1","volume-title":"Seminars in Immunology","author":"Dinarello C. A.","year":"2013"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.4c00205"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.02.006"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210400"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.02.016"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109436"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.557170"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00459"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106963"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2024.120740"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-021-00279-8"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-1638-7"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06449-x"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.16"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11142223"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101192"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01687-y"},{"key":"e_1_2_12_101_1","first-page":"2025","article-title":"NLRP3 Inflammasome in Alzheimer's Disease: Molecular Mechanisms and Emerging Therapies","volume":"16","author":"Li Z.","year":"2025","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2024.10.004"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606854104"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02596"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30634"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.95"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.02.045"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117123"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1207830"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.10"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1376-1"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00241-9"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-221072"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132081"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1169-6"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2018.e00971"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2024.111045"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107530"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01806-4"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01806-4"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.07.003"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.11.019"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.142"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2011.0288"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-024-00550-7"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1278521"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00752"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47435"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25010020"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75889"},{"key":"e_1_2_12_131_1","first-page":"1579","article-title":"Interleukin\u201038 (IL\u201038) Is A Novel Biochemical Marker in Sera of Iraqi Patients With Alzheimers Disease","volume":"21","author":"Yahya A. M.","year":"2021","journal-title":"Biochemical and Cellular Archives"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.127.6.2517"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6436"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20308"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.990307"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-2-15"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604032113"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)01343-G"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.70460","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:00:32Z","timestamp":1775973632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.70460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":137,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/jbt.70460"],"URL":"https:\/\/doi.org\/10.1002\/jbt.70460","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"assertion":[{"value":"2025-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70460"}}