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The link between diseases including obesity, neurodevelopmental disorders, liver fibrosis and DM treatment has been elucidated in organisms that exposed DM. Also, in aquatic organisms, hepatopancreatic necrosis disease, impaired cellular development, and decreased mobility could be related to DM treatment for pond cleaning and fending off arthropods causing diseases such as Caligidosis. Apart from that, DM resistance in target organisms has been a staggering issue due to the prevalence of DM\u2010resistant insects, which make challenging to overcome vector\u2010borne diseases, agricultural corps' yield, and economic loss in aquaculture. Using omics analysis in organisms exposed to DM, systems biology tools have provided a detailed understanding of the interactions among genes, proteins, metabolites, and microbiota at molecular level. This review underscores the mechanisms of how DM leads to toxicity in model and nontarget organisms, and how target organisms evolve from being susceptible to resistant as a molecular response. Overall, an in\u2010depth analysis of the molecular mechanisms behind DM exposure will provide a comprehensive understanding of the DM application for its risk assessment.<\/jats:p>","DOI":"10.1002\/jbt.70469","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T14:14:01Z","timestamp":1758204841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gaining Biological Insights Into Deltamethrin\u2010Induced Toxicity and Resistance at the Molecular Level"],"prefix":"10.1002","volume":"39","author":[{"given":"Mustafa","family":"Yavuz","sequence":"first","affiliation":[{"name":"Department of Mycotoxins,Denizli Food Control Laboratory Directorate Ministry of Agriculture and Forestry Denizli T\u00fcrkiye"},{"name":"Department of Bioengineering Marmara University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Recep Anil","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Marmara University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceyhun","family":"Bereketoglu","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Marmara University Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-9712","authenticated-orcid":false,"given":"Beste","family":"Turanli","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Marmara University Istanbul T\u00fcrkiye"},{"name":"Health Biotechnology Common Application and Research Center of Excellence (SABIOTEK) Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b02253"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2018.1474283"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-022-00860-0"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2015.01.002"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1584\/jpestics.30.75"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228623"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2021.109095"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.113870"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.132082"},{"key":"e_1_2_14_11_1","article-title":"Developmental Pyrethroid Exposure Disrupts Molecular Pathways for Circadian Rhythms and Synaptic Plasticity in Mouse Brain","author":"Nguyen J. 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