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However, its clinical application is hindered by poor water solubility, a short half\u2010life, and nonspecific toxicity. In this study, we utilized nanotechnology to develop a novel dual\u2010targeted nanocomplex, termed PLGA@AC@FSHL\u2010M (PAMF) nanoparticles (NPs), comprising poly(lactic\u2010co\u2010glycolic acid) (PLGA) encapsulating AC and camouflaged with a macrophage membrane modified by the FSHL81\u201095 peptide. This design enabled efficient delivery of AC while simultaneously targeting granulosa cells (GCs). Our findings demonstrated that PAMF NPs significantly reduced the production of tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), and interleukin\u20101\u03b2 (IL\u20101\u03b2) in lipopolysaccharide (LPS)\u2010induced KGN cells. Furthermore, AC\u2010loaded PAMF NPs enhanced nuclear translocation of nuclear factor erythroid 2\u2013related factor 2 (Nrf2) and upregulated heme oxygenase\u20101 (HO\u20101), while inhibiting NF\u2010\u03ba\u03b2 activation. These results suggest that biomimetic AC\u2010loaded nanoparticles effectively suppress apoptosis and promote proliferation under inflammatory conditions in KGN cells, offering a promising therapeutic strategy for DOR.<\/jats:p>","DOI":"10.1002\/jbt.70495","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T14:28:11Z","timestamp":1758205691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Nanoparticles Loaded With \u03b1\u2010Cyperone Alleviating LPS\u2010Induced Inflammation in KGN Cells by Activating Nrf2\/HO\u20101 and Suppressing ROS"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8594-9519","authenticated-orcid":false,"given":"Jialing","family":"Li","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center General Hosptial of Ningxia Medical University Yinchuan 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