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These compounds (2,3,5,6 (a\u2013f)) were characterized by IR,\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR, and\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010NMR studies. Acarbose was used as a standard for alpha glycosidase and alpha amylase enzymes, while tacrine molecule was used as a standard for acetylcholinesterase enzyme. While the IC\n                    <jats:sub>50<\/jats:sub>\n                    result of acarbose was found to be 6.430\u2009\u00b1\u20090.736, the IC\n                    <jats:sub>50<\/jats:sub>\n                    values for \u03b1\u2010gly and \u03b1\u2010amly enzymes were 1.454\u2009\u00b1\u20090.087\u2009\u00b5M\u20133.7973\u2009\u00b1\u20090.3352\u2009\u00b5M and 1.509\u2009\u00b1\u20090.161\u2009\u00b5M\u20133.797\u2009\u00b1\u20090.335\u2009\u00b5M, respectively. In addition, the IC\n                    <jats:sub>50<\/jats:sub>\n                    values for AChE enzyme were found to be in the range of 1.330\u2009\u00b1\u20090.118\u2009\u00b5M\u201311.104\u2009\u00b1\u20093.463\u2009\u00b5M. Except for molecules 5a, 5b and 5\u2009f, all other molecules were found to be more active than the standard. Molecular docking simulations were conducted to explore the interactions of 3e and 3\u2009f compounds with Human Acetylcholinesterase, using tacrine as a reference molecule, to evaluate binding affinities and key ligand\u2010protein interactions.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70510","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T15:56:42Z","timestamp":1757951802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["New methyl\/benzyl\u20101,2,4\u2010triazole\u20103\u2010one Derivatives: Synthesis, Characterization (IR, NMR), Antidiabetic, Anti\u2010Alzheimer, and Molecular Docking Study"],"prefix":"10.1002","volume":"39","author":[{"given":"Fatih","family":"\u00c7elik","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Karadeniz Technical University Trabzon 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