{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:05:43Z","timestamp":1790543143398,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sepsis is a medical condition that occurs when a harmful inflammatory response damages tissues and organs. The kidneys are among the organs most frequently affected by sepsis. Anti\u2010inflammatory strategies are crucial in treating sepsis. The anti\u2010inflammatory properties of sulphasalazine (SFZ) have been demonstrated in various in vitro and in vivo studies. This study investigates the effect of SFZ on kidney damage in a rat model of sepsis induced by the cecal ligation and puncture (CLP) method. Animals were divided into control, CLP, CLP\u2009+\u2009SFZ50, and CLP\u2009+\u2009SFZ250. Two doses of SFZ (50 and 250\u2009mg\/kg) were applied in two different treatment groups after CLP. The administration of SFZ reduced the CLP\u2010induced increase in serum blood urea nitrogen (BUN), tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), interleukin\u20101 beta (IL\u20101\u03b2), neutrophil gelatinase\u2010associated lipocalin (NGAL), interleukin\u201018 (IL\u201018), kidney injury molecule\u20101 (KIM\u20101), and creatinine (Cre) levels for both doses (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Additionally, SFZ treatment significantly decreased histopathological damage, phosphorylated NF\u2010\u03baB, toll\u2010like receptor\u20104 (TLR\u20104), IL\u20101\u03b2, phosphorylated I\u03baB\u2010\u03b1, interleukin\u20106 (IL\u20106), TNF\u2010\u03b1, caspase\u20103, and caspase\u20108 levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In this study, we found that two different doses of SFZ (50 and 250\u2009mg\/kg) showed protective effects by decreasing inflammation and kidney damage in a CLP\u2010induced experimental sepsis model.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70513","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T15:57:44Z","timestamp":1757951864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Sulfasalazine on Renal Damage in Sepsis Model Induced by Cecal Ligation and Puncture in Rats"],"prefix":"10.1002","volume":"39","author":[{"given":"Zeynep","family":"\u00c7i\u00e7ek","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Yozgat Bozok Yozgat 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