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Chitosan\u2010based delivery systems, especially polymeric nanoparticles, have been a strategy to improve curcumin's solubility, stability, and provide targeted drug delivery. This review maps evidence on the use of delivery systems based on the natural polymer chitosan incorporating curcumin for disease management, highlighting their potential to enhance therapeutic outcomes. The review included studies involving humans, animals, or cell cultures using chitosan\u2010based systems for curcumin delivery for therapeutical purposes. A systematic search was performed in PubMed, EMBASE, Web of Science Core Collection, and Google Scholar (January 16, 2025). Two independent reviewers selected studies, and data were synthesized descriptively. Bibliometric analysis was conducted using VOSviewer. From 5336 records, 387 studies met inclusion criteria. Cancer (212 studies) and wound healing (112 studies) were the predominant topics. 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Chitosan\u2010based formulations containing curcumin have demonstrated strong potential in cancer treatment and wound healing care.<\/jats:p>","DOI":"10.1002\/jbt.70515","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:55:19Z","timestamp":1758790519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chitosan\u2010Based Systems for Curcumin Delivery: Evidence for Therapeutic Applications"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-232X","authenticated-orcid":false,"given":"Mylene Martins","family":"Monteiro","sequence":"first","affiliation":[{"name":"Laboratory of Oral Histopathology, Health Sciences Faculty University of Bras\u00edlia Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-8388","authenticated-orcid":false,"given":"Bruna","family":"Bastos 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