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HBV exposure markedly upregulated OCT4 and miR\u20101246 expression in both HepAD38 and HepG2\u2010NTCP cell lines. These effects were reversed by entecavir treatment or the Hepatitis B X (HBx) knockdown. Furthermore, overexpression of OCT4 enhanced expression of miR\u20101246, \u03b2\u2010catenin, and LF\u2010associated genes in LX2 (Hepatic stellate cell) cells. Interestingly, exosomes from HBV infected HepG2\u2010NTCP cells upregulated OCT4\/miR\u20101246\/\u03b2\u2010catenin expression as well as \u03b1\u2010SMA, Col1A and TIMP\u20101 in LX2 cells. These fibrogenic effects were inhibited by HBx gRNA. Moreover, 26 HBV infected patients were enrolled in this study. The expression of miR\u20101246 and \u03b2\u2010catenin in liver tissue were strongly correlated with LF. These results showed that HBV induced LF through exosomal OCT4\/miR\u20101246\/\u03b2\u2010catenin Pathway, which lay a basis for LF treatment.<\/jats:p>","DOI":"10.1002\/jbt.70521","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T06:36:56Z","timestamp":1758782216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exosome Carrying OCT4\/miR\u20101246\/\u03b2\u2010catenin Deriving From HBV Infected Hepatocytes Accelerated Liver Fibrosis"],"prefix":"10.1002","volume":"39","author":[{"given":"Tiantian","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine The First Affiliated Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuankun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Tropical and Liver Diseases The Second Affiliated Hospital of Hainan Medical University Haikou Hainan China"},{"name":"Department of Clinical Laboratory The Second Affiliated Hospital of Hainan Medical University Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The First Affiliated Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qionghan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The First Affiliated Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhua","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Tropical and Liver Diseases The Second Affiliated Hospital of Hainan Medical University Haikou Hainan China"},{"name":"Department of Internal Medicine The Hainan Public Health Clinical Center Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Medicine People's Hospital of Zhengzhou University Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7734-4838","authenticated-orcid":false,"given":"Wenting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The First Affiliated Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID9.0000000000000128"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9675-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040875"},{"issue":"10","key":"e_1_2_8_5_1","first-page":"612","article-title":"[Dynamic Evolution of MMP\u201013, TIMP\u20101, Type I and III collagen and Their Interaction in Experimental Liver Fibrosis]","volume":"12","author":"Zhu Y. 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