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The assay for transposase\u2010accessible chromatin by sequencing (ATAC\u2010seq) was employed to investigate chromatin reshaping associated with SICD in the sepsis mouse model. ATAC\u2010seq data were generated from the hearts of sepsis mice, and the relationship between chromatin accessibility and gene expression was analyzed in conjunction with RNA sequencing. RNA\u2010seq results indicated that the most differentially expressed genes were present 1 day post\u2010induction. We identified 2389 increased and 5065 decreased sepsis\u2010associated chromatin\u2010accessible regions in the heart tissues of sepsis mice. At 1 day post\u2010induction, 877 genes were upregulated, and 881 were downregulated. Notably, an enhanced ATAC\u2010seq signal was observed in approximately 1311 genes, with 93 showing upregulated mRNA levels. The signatures of numerous transcription factors, including ERG, ETV2, Mef2c, and JunB, were enriched in the SICD\u2010associated accessible chromatin regions. This study demonstrates that alterations in chromatin accessibility may serve as an initial mechanism in sepsis\u2010induced cardiac dysfunction.<\/jats:p>","DOI":"10.1002\/jbt.70543","type":"journal-article","created":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T18:07:42Z","timestamp":1759687662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of the Chromatin Accessibility in the Hearts of Mice With Lipopolysaccharide (LPS)\u2010Induced Sepsis"],"prefix":"10.1002","volume":"39","author":[{"given":"Hao\u2010jie","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University Fuzhou China"},{"name":"Department of Anesthesiology, the First Affiliated Hospital Fujian Medical University Fuzhou China"},{"name":"Institute of Anesthesiology Fujian Medical University 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