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Taxifolin, a phytochemical flavonoid, possesses potent free radical\u2010scavenging activity and the ability to modulate inflammatory responses. Our study focused on assessing the renoprotective capacity of taxifolin in the context of cisplatin\u2010induced kidney damage. Cell culture studies showed that taxifolin reduced damage to human tubular epithelial cells caused by cisplatin. Furthermore, we evaluated the protective effect of taxifolin on mice with cisplatin\u2010induced nephrotoxicity. Oral administration of taxifolin effectively mitigated both functional impairment and structural injury in renal tubules, both when administered 2 days before and 2\u2009h following cisplatin injection. Transcriptomic analysis of renal tissues via RNA\u2010seq revealed that taxifolin's nephroprotective effects against cisplatin toxicity may involve Fabp4\u2010regulated lipid metabolism pathways. In both cisplatin\u2010induced AKI mouse models and renal tubular cells, taxifolin enhanced lipid metabolism, restored cellular energy (ATP) production, and upregulated PGC\u20101\u03b1\/PPAR\u03b1 expression by reversing Fabp4\u2010impaired suppression of fatty acid beta\u2010oxidation. Collectively, these results indicate that taxifolin exerts nephroprotective effects against cisplatin\u2010induced AKI by modulating Fabp4\u2010dependent fatty acid oxidation pathways, positioning it as a potential therapeutic candidate for cisplatin\u2010associated nephrotoxicity.<\/jats:p>","DOI":"10.1002\/jbt.70559","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:41:37Z","timestamp":1759794097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Taxifolin Attenuates Cisplatin\u2010Induced Acute Kidney Injury by Promoting Fatty Acid Oxidation"],"prefix":"10.1002","volume":"39","author":[{"given":"Xuejin","family":"Jin","sequence":"first","affiliation":[{"name":"Affiliated Yongkang First People's Hospital Hangzhou Medical College Yongkang China"},{"name":"Zhejiang TCM Key Laboratory of Pharmacology and Translational Research of Natural Products, School of Pharmaceutical 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