{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:59:47Z","timestamp":1785437987903,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Organophosphorus flame retardants (OPFRs) are recognized as potential endocrine disruptors. Several studies have demonstrated that contamination with OPFRs increases the risk of infertility. Our prior research showed that inhibition of the nuclear factor erythroid\u2010derived 2\u2010related factor (Nrf2)\/p53 signaling pathway is an essential regulator of DPhP\u2010induced reproductive injury. In this study, we aimed to uncover potential epigenetic mechanisms involved in DPhP\u2010induced GC\u20102 cell dysfunction. Our results established that DPhP promoted miR\u2010128\u20103p expression in GC\u20102 cells, targeted the Nrf2 signaling pathway, thereby suppressing its activity, and thus inhibited autophagy to promote apoptosis. These findings indicate that DPhP causes reproductive damage and potentially modulates autophagy and apoptosis in GC\u20102 cells through the miR\u2010128\u20103p\/Nrf2 regulatory axis. Our results further elucidated the possible mechanism of DPhP\u2010induced reproductive damage and provided new clues to study the potential reproductive toxicity of OPFRs.<\/jats:p>","DOI":"10.1002\/jbt.70563","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T06:46:38Z","timestamp":1761115598000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of miR\u2010128\u20103p\/Nrf2 Axis in DPhP\u2010Induced GC\u20102spd(ts) Apoptosis and Inhibition of Cellular Autophagy"],"prefix":"10.1002","volume":"39","author":[{"given":"Qi","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Radiology, Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zidi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9010-4051","authenticated-orcid":false,"given":"Haoyuan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Health Toxicology, School of Public Health Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Health Toxicology, School of Public Health Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Fuwai Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weida","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing TSP \u2013 Pharmaron Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2538-9446","authenticated-orcid":false,"given":"Yu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Health Toxicology, School of Public Health Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c03948"},{"key":"e_1_2_10_3_1","unstructured":"TSCA. 2024. 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