{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:12Z","timestamp":1786978092234,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Dimethyl fumarate (DMF) is approved for treating autoimmune and inflammatory diseases; however, its effectiveness in rheumatoid arthritis (RA) has not been thoroughly studied. This study used a collagen\u2010induced arthritis (CIA) rat model to evaluate the effects of DMF on RA in vivo. Lewis rats were used to create an arthritis model using bovine type II collagen (CII) emulsified with incomplete Freund's adjuvant (IFA). Five groups of rats were randomly selected: vehicle\u2010treated rats, DMF\u2010treated rats, CIA\u2010controlled rats, normal control rats, and methotrexate (MTX)\u2010treated rats. Arthritis score and the measurement of hind paw swelling were measured as part of the clinical evaluation. Rats were sacrificed on day 28, and the hind ankle joints were collected for radiography and histological analysis. ELISA was also used to measure the plasma levels of tumor necrosis factor alpha (TNF\u2010\u03b1) and anti\u2010CII. DMF significantly reduced joint inflammation, cartilage degradation, CIA\u2010induced arthritis score, and hind paw swelling. TNF\u2010\u03b1 and anti\u2010CII levels were lower in the DMF\u2010treated group than in the CIA control group. The immunoregulatory activity of DMF may have contributed to its amelioration of RA. DMF might be studied as a possible new medicinal agent for the treatment of RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbt.70576","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:30:38Z","timestamp":1761895838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dimethyl Fumarate Suppresses Collagen\u2010Induced Arthritis by Regulating Inflammatory Responses"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7826-1185","authenticated-orcid":false,"given":"Parisa","family":"Zafari","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Ghaffari","sequence":"additional","affiliation":[{"name":"Orthopedic Research Center, Faculty of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima Makvand","family":"Gholipour","sequence":"additional","affiliation":[{"name":"Department of Stem Cells and Developmental Biology, Cell Science Research Center Royan Institute for Stem Cell Biology and Technology, ACECR Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansooreh","family":"Mirzaei Geleh Colaei","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Faramarzi","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1766-6605","authenticated-orcid":false,"given":"Alireza","family":"Rafiei","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-018-0016-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-814307-0.00046-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2017.08.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.213"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2024.1098.1111"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113126"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-3369"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2018.07.004"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2018.1434793"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2020.1736553"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph13100306"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9080700"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S342280"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70345"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-022-01759-1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111617"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2023.01.373"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","unstructured":"S.Saha L.Saha N.Singh et al. 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