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Our objective was to assess the hepatoprotective effect of vitamin D against BPA\u2010induced hepatic oxidative stress, liver inflammation, and apoptosis in rats. Therefore, rats were exposed to BPA alone (25\u2009mg\/kg) or treatment with vitamin D (400 IU\/day) for 30 days. Vitamin D may be crucial in safeguarding the liver by functioning as an antioxidant, anti\u2010inflammatory, and antiapoptotic agent in BPA\u2010induced hepatic injury. The treatment of Vitamin D reversed the liver damage caused by BPA by reducing the levels of AST, ALT, and ALP in the serum. Vitamin D also improved the activity of antioxidant enzymes such as SOD and CAT, as well as the levels of liver antioxidants like GSH and TAS. Additionally, vitamin D suppressed liver inflammation and hepatic oxidative stress in rats exposed to BPA. Furthermore, vitamin D treatment alleviated the disruptions in liver structure and reduced TUNEL staining, an indicator of apoptosis, in BPA\u2010induced liver damage. In conclusion, this study demonstrated that vitamin D treatment is a powerful protective agent against liver damage in BPA\u2010exposed rats, achieved through the regulation of oxidant\/antioxidant balance, suppression of apoptosis, and reduction of pro\u2010inflammatory cytokine release.<\/jats:p>","DOI":"10.1002\/jbt.70588","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:46:56Z","timestamp":1762411616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D Exhibits Hepatoprotective Properties Against Bisphenol A\u2010Induced Hepatic Injury in Rats via Mitigating Oxidative Stress, Inflammation, and Apoptosis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3047-906X","authenticated-orcid":false,"given":"Abdulaziz Hasan Ahmed Mohsen","family":"Saif","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, 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