{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:59:48Z","timestamp":1785437988582,"version":"3.56.0"},"reference-count":68,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cirrhosis is a chronic liver disease that is characterized by fibrosis and nodule formation that lead to alteration of the normal lobular organization of the liver. This study aimed to elucidate the antioxidant, antiapoptotic, and histological effects of taurine (TAU) and metformin (MET), both alone and in combination, in thioacetamide (TAA)\u2010induced liver cirrhosis in rats. Liver cirrhosis was induced by injection of TAA (200\u2009mg\/kg\/three times\/week for 6 weeks). The treated groups were administered MET (200\u2009mg\/kg\/day, p.o.), TAU (100\u2009mg\/kg\/day, i.p.), and a combination of both for 5 weeks after TAA injection. The hallmarks of TAA\u2010induced liver cirrhosis include increased oxidative stress, apoptosis, and decreased antioxidant levels in the liver tissue. This revealed that MET and TAU were used to treat TAA\u2010induced liver damage. MET and TAU enhanced antioxidant systems by increasing superoxide dismutase, glutathione\u2010S\u2010transferase, and catalase and lowering malondialdehyde and nitric oxide levels. Furthermore, MET and TAU inhibited apoptosis through Bcl\u20102, Bax, and caspase\u20103 signaling pathways. These biochemical results were confirmed by liver histopathological analysis. Overall, posttreatment with MET and TAU demonstrated significant and synergizing protective effects against TAA\u2010induced cirrhosis.<\/jats:p>","DOI":"10.1002\/jbt.70599","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T07:51:55Z","timestamp":1762847515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Synergistic Hepatoprotective Action of Metformin and Taurine in a Rat Model of Liver Cirrhosis"],"prefix":"10.1002","volume":"39","author":[{"given":"Sherouk S.","family":"Badawy","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad M.","family":"Mashaly","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Damietta University New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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