{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:46:08Z","timestamp":1771047968269,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The number of acute liver failure cases is rising worldwide as a result of both external and internal factors. This demonstrates a significant risk to global human health and well\u2010being. The excessive use of synthetic drugs mostly causes the occurrence of liver failure. The present study aims to investigate the therapeutic efficacy of bavachalcone in preventing acetaminophen (APAP)\u2010induced liver damage in mice. To develop liver toxicity, the animals were administered 300\u2009mg\/kg of APAP via the intraperitoneal route for 3 days. The mice were pretreated with 10 and 20\u2009mg\/kg of bavachalcone by oral route 1\u2009h before the APAP administration. The silymarin (50\u2009mg\/kg) was utilized as a standard hepatoprotective drug to compare the results of bavachalcone treatment. After the completion of the treatments, the body weight and relative liver weight of the mice were assessed. The levels of liver marker enzymes, oxidative stress markers, antioxidant levels, and inflammatory cytokines were evaluated using kits. The hepatic tissues obtained from the experimental mice were utilized for the histological methods. The treatment of bavachalcone at concentrations of 10 and 20\u2009mg\/kg effectively lowered body weight and slightly decreased liver mass in the APAP\u2010induced mice. The bavachalcone treatment also led to elevated antioxidant levels and effectively reduced oxidative stress markers. Bavachalcone treatment also decreased the levels of inflammatory cytokines and liver marker enzymes in the APAP\u2010induced mice. The histopathological examination of liver tissues further validated the therapeutic potential of bavachalcone. The findings of the current study highlight the beneficial properties of bavachalcone in protecting against APAP\u2010induced liver injury in mice. Therefore, it possesses the potential to serve as an effective therapeutic choice for treating liver toxicity.<\/jats:p>","DOI":"10.1002\/jbt.70623","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T04:07:11Z","timestamp":1764562031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bavachalcone Protects Against Acetaminophen\u2010Induced Acute Liver Toxicity in Mice by Inhibiting Inflammation and Oxidative Stress Responses"],"prefix":"10.1002","volume":"39","author":[{"given":"Tian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Oncology, Shandong Public Health Clinical Center Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songlan","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Portal Hypertension Intervention, Shandong Public Health Clinical Center Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"An","sequence":"additional","affiliation":[{"name":"Department of Portal Hypertension Intervention, Shandong Public Health Clinical Center Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shandong Public Health Clinical Center Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansour K.","family":"Gatasheh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Science King Saud University Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anis","family":"Ahamed","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology, College of Science King Saud University Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4123-0652","authenticated-orcid":false,"given":"Fei","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shandong Public Health Clinical Center Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-021-10144-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02885-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848231163410"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.1896"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2019.08.037"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.02.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2020.12.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191353"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-018-0653-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/01926233231171101"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3320325"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.10.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12071316"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.4010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4ra05370b"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.12.030"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.03.007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.04.104"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.04.029"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/958937"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110552"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.5530\/ijper.20257230"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2023.09.006"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.11.031"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-00663-0_12"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2018.1491547"},{"key":"e_1_2_9_28_1","volume-title":"Acute Liver Failure, In StatPearls","author":"Shah N. 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