{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:58:15Z","timestamp":1790344695591,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Obesity and its associated metabolic disorders pose a significant global health challenge. The gut microbiota, influenced by dietary factors, plays a crucial role in regulating lipid metabolism and glucose homeostasis. This review explores the potential of curcumin, a polyphenol derived from turmeric, as an epigenetic modulator in obesity management. Curcumin exhibits diverse biological activities, including the ability to modulate gut microbiota composition, enhance intestinal barrier integrity, and regulate long non\u2010coding RNA (lncRNA) expression. By influencing these pathways, curcumin effectively mitigates obesity\u2010related inflammation, improves insulin sensitivity, and reduces hepatic steatosis. Clinical and preclinical studies demonstrate that curcumin supplementation can significantly improve obesity\u2010related markers, particularly in bioavailability\u2010enhanced formulations. We highlight key mechanistic gaps and propose targeted in vitro, in vivo, and clinical studies to validate curcumin\u2013SNHG9 interactions as a novel epigenetic therapy for obesity.<\/jats:p>","DOI":"10.1002\/jbt.70635","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T07:12:21Z","timestamp":1765264341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mechanistic Insights Into Curcumin's Epigenetic and Gut Microbiota\u2010Mediated Regulation of Obesity\u2010Linked Endocrine Dysfunction"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3794-1416","authenticated-orcid":false,"given":"Manoj Kumar","family":"Narasimhan","sequence":"first","affiliation":[{"name":"Department of Genetic Engineering School of Bioengineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District 603203, India Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-3173","authenticated-orcid":false,"given":"Nila","family":"Ganamurali","sequence":"additional","affiliation":[{"name":"Helix Research Lab, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha University Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4170-9855","authenticated-orcid":false,"given":"Evelyn Sharon","family":"S","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy, Dr.M.G.R. Education and Research Institute Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0792-392X","authenticated-orcid":false,"given":"Sarvesh","family":"Sabarathinam","sequence":"additional","affiliation":[{"name":"Helix Research Lab, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha University Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2024.11.068"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-025-10461-1"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obmed.2023.100497"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/801418"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010167"},{"key":"e_1_2_16_7_1","first-page":"2023","article-title":"Curcumin Derived From Medicinal Homologous Foods: Its Main Signals in Immunoregulation of Oxidative Stress, Inflammation, and Apoptosis","volume":"14","author":"Hu P.","year":"2023","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S467882"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S536551"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.809952"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020639"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12040642"},{"issue":"6","key":"e_1_2_16_13_1","first-page":"2735","article-title":"Curcumin: A Polyphenol With Molecular Targets for Cancer Control","volume":"17","author":"Qadir M. 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