{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:07:14Z","timestamp":1787591234933,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Transient receptor potential vanilloid\u20101 (TRPV1) channels have been shown to be present in many tissues, including the kidney. Previous studies have reported that TRPV1 activation has anti\u2010inflammatory and renoprotective effects. In this study, we investigated the effects of TRPV1 agonist capsaicin on acute kidney injury (AKI) in a rat sepsis model induced by cecal ligation and puncture (CLP). Rats were divided into control, CLP and treatment groups in which 3 different doses of capsaicin (2, 6 and 30\u2009mg\/kg) were administered with CLP administration. Kidney tissues and sera from animals 24\u2009h after CLP were analyzed. Histopathological examinations have shown that kidney damage occurs due to sepsis. TLR4\/NF\u2010\u03baB activity, proinflammatory cytokines (IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1), caspase\u20103, caspase\u20108 and malondialdehyde levels increased in renal tissue due to sepsis. Serum levels of IL\u20101\u03b2, TNF\u2010\u03b1 and renal damage biomarkers (BUN, CRE, IL\u201018 and NGAL) increased due to sepsis. Capsaicin administration dose\u2010dependently reversed sepsis\u2010induced pathological changes in the kidney and serum. Our findings suggest that the TRPV1 agonist capsaicin has renoprotective effects in sepsis\u2010induced AKI by reducing inflammation, oxidative damage and apoptosis. TRPV1 activation may be a promising therapeutic strategy to ameliorate sepsis\u2010induced kidney and other organ damage.<\/jats:p>","DOI":"10.1002\/jbt.70637","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T18:46:24Z","timestamp":1765392384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Protective Effects of TRPV1 Agonist Capsaicin in Sepsis\u2010Induced Acute Kidney Injury in Rats"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1141-069X","authenticated-orcid":false,"given":"Burak","family":"Bircan","sequence":"first","affiliation":[{"name":"Department of Medical Services and Techniques Osmaniye Korkut Ata University, Vocational School of Health Services Osmaniye Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2066-829X","authenticated-orcid":false,"given":"Murat","family":"\u00c7akir","sequence":"additional","affiliation":[{"name":"Department of Physiology Yozgat Bozok University, Faculty of Medicine Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Yozgat Bozok University, Faculty of Medicine Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8586-3433","authenticated-orcid":false,"given":"Semanur","family":"Firat","sequence":"additional","affiliation":[{"name":"Department of Physiology Yozgat Bozok University, Faculty of Medicine Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-4454","authenticated-orcid":false,"given":"G\u00fcldeniz","family":"\u015eekerci","sequence":"additional","affiliation":[{"name":"Department of Physiology \u0130n\u00f6n\u00fc University, Faculty of Medicine Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6z","family":"Samet","sequence":"additional","affiliation":[{"name":"Department of Veterinary Osmaniye Korkut Ata University, Vocational School of Health Services Osmaniye Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-1802","authenticated-orcid":false,"given":"Suat","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Physiology \u0130n\u00f6n\u00fc University, Faculty of Medicine Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4683-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-017-0639-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001672"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3925"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5455\/medscience.2019.08.9045"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00477.2005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.4.1800-1816.2004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31828fade1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61815-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201211-1983OC"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010050484"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00414.2005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00469.2013"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020791"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.4.0010"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.07.082"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2014.2322"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1179\/135100001101536120"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(02)00335-5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(94)90198-8"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000191414.94461.7e"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1488-4_1"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70132"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70513"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","unstructured":"T. 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