{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:18:22Z","timestamp":1792534702718,"version":"4.5.0"},"reference-count":78,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Delphinidin, a bioactive anthocyanidin found in pigmented fruits and vegetables, exhibits remarkable therapeutic potential due to its antioxidant, anti\u2010inflammatory, and anti\u2010cancer properties. This review synthesizes current knowledge on delphinidin's structure, dietary sources, stability challenges, and mechanisms of action. As a potent antioxidant, it scavenges reactive oxygen species (ROS) and upregulates endogenous defenses via the Nrf2 pathway, mitigating oxidative stress in chronic diseases. Delphinidin suppresses inflammation by inhibiting NF\u2010\u03baB and MAPK signaling, reducing pro\u2010inflammatory cytokines like TNF\u2010\u03b1 and IL\u20106. Its anti\u2010cancer effects include apoptosis induction, cell cycle arrest, and inhibition of angiogenesis and metastasis through modulation of VEGF, MMPs, and PI3K\/Akt pathways. Additionally, delphinidin demonstrates cardioprotective effects by enhancing endothelial function and reducing LDL oxidation, while its neuroprotective actions involve attenuating neuroinflammation and amyloid\u2010\u03b2 aggregation in neurodegenerative disorders. The compound also improves metabolic health by enhancing insulin sensitivity and inhibiting \u03b1\u2010glucosidase. However, delphinidin's pH and thermal instability limit its clinical application, prompting research into encapsulation and nano\u2010delivery systems to enhance bioavailability. This review underscores delphinidin's promise as a nutraceutical or adjunctive therapy while highlighting the need for further studies to validate its efficacy in humans and optimize delivery methods.<\/jats:p>","DOI":"10.1002\/jbt.70655","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T04:46:12Z","timestamp":1766378772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Delphinidin: A Multifaceted Anthocyanidin With Therapeutic Potential in Chronic Diseases"],"prefix":"10.1002","volume":"39","author":[{"given":"Bidemi Emmanuel","family":"Ekundayo","sequence":"first","affiliation":[{"name":"Department of Biochemistry Bamidele Olumilua University of Science and Technology Ikere\u2010Ekiti Ekiti State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham Olabode","family":"Ademola","sequence":"additional","affiliation":[{"name":"Phytomedicine and 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