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Male Sprague\u2010Dawley rats were divided into four groups: Control, Dox, Dox+GAL 50\u2009mg\/kg, and Dox+GAL 100\u2009mg\/kg. GAL significantly attenuated Dox\u2010induced damage by reducing IL\u20106 and 8\u2010OHdG levels, restoring AQP\u20101 expression, and improving histopathological profiles. Biochemical analysis demonstrated GAL's antioxidant activity, evidenced by elevated levels of glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT), alongside decreased levels of malondialdehyde (MDA). These findings suggest GAL as a potential therapeutic agent for mitigating Dox\u2010induced organ toxicity, with broader implications for conditions involving oxidative stress and inflammation.<\/jats:p>","DOI":"10.1002\/jbt.70669","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T10:48:17Z","timestamp":1767005297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Effects of Galangin Mitigating Doxorubicin\u2010Induced Hepatorenal Injury"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9903-8759","authenticated-orcid":false,"given":"Fazile Nur","family":"Ekinci Akdemir","sequence":"first","affiliation":[{"name":"Department of Physiology Erzurum Medicine Faculty Health Sciences University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8588-1035","authenticated-orcid":false,"given":"Mustafa Can","family":"G\u00fcler","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersen","family":"Eraslan","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine Band\u0131rma OnYedi Eyl\u00fcl University Bal\u0131kesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0095-0917","authenticated-orcid":false,"given":"Ayhan","family":"Tanyeli","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Atat\u00fcrk University Erzurum Turkey"},{"name":"Department of Pathology Faculty of Veterinary Medicine Kyrgyz\u2010Turkish Manas University Bishkek Kyrgyzstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-2479","authenticated-orcid":false,"given":"Fatih Mehmet","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Aksaray University Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8222-5515","authenticated-orcid":false,"given":"Sefa","family":"K\u00fc\u00e7\u00fckler","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Veterinary Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12040659"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/hep.15.41"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2024.110140"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2024.101737"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27072122"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327115626581"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2024.106626"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114087"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01565-0"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25073625"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17070963"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.05.007"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-16804-z"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7874"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2013.09.001"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155989"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejbt.2021.05.005"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2024.107855"},{"issue":"11","key":"e_1_2_11_20_1","first-page":"1382","article-title":"The Investigation of the Effect of Fraxin on Hepatotoxicity Induced by Cisplatin in Rats","volume":"23","author":"Akdemir F. 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