{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:25:11Z","timestamp":1777868711595,"version":"3.51.4"},"reference-count":73,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Rifampicin (RF) is a primary anti\u2010tuberculosis medication utilized in tuberculosis treatment, and its concurrent administration with other medications, as well as the duration of therapy, may result in adverse effects. While the hepatotoxicity of RF is established, its impact on the spleen remains unexamined. Thus, our study aimed to investigate the impact of RF on the spleen and the protective role of Linalool (LN), a monoterpene, through the Heme oxygenase\u20101 (HO\u20101) enzyme pathway, with biochemical analyses, oxidative stress parameters, protein levels, and histopathological assessments. In the study, thirty healthy adult male Sprague\u2010Dawley rats were randomly allocated into five groups: control, solvent control (dimethyl sulfoxide \u2010 DMSO), RF, LN, and RF\u2009+\u2009LN. Spleen tissues and blood specimens were collected from the rats for examination. RF markedly elevated total and indirect bilirubin, Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , HO\u20101, and MDA levels, while diminishing GSH levels. Conversely, in the RF\u2009+\u2009LN group, total and indirect bilirubin, Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , HO\u20101, and MDA levels were dramatically reduced, whereas GSH levels were elevated. Histopathologically, RF\u2010induced defects were ameliorated in the LN\u2010treated cohorts. In conclusion, rifampicin exhibited toxic effects on the spleen, which were mitigated by LN.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70680","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:56:11Z","timestamp":1767588971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heme Oxygenase\u20101 Mediated Protective Effects of Linalool on Rifampicin\u2010Induced Spleen Toxicity Through the PI3K\/Akt Pathway"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2446-1517","authenticated-orcid":false,"given":"Ay\u015feg\u00fcl","family":"Acet","sequence":"first","affiliation":[{"name":"Department of Medical Biology Faculty of Medicine Ad\u0131yaman University Ad\u0131yaman Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9040-6773","authenticated-orcid":false,"given":"Sebile","family":"Az\u0131rak","sequence":"additional","affiliation":[{"name":"Vocational School of Health Services Ad\u0131yaman University Ad\u0131yaman Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9726-5846","authenticated-orcid":false,"given":"Ebru","family":"Anna\u00e7","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Faculty of Medicine Ad\u0131yaman University Ad\u0131yaman Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1483-2580","authenticated-orcid":false,"given":"\u0130brahim","family":"Bozgeyik","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Faculty of Medicine Ad\u0131yaman University Ad\u0131yaman Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4310-6238","authenticated-orcid":false,"given":"Halime Tozak","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Faculty of Medicine K\u0131r\u015fehir Ahi Evran University K\u0131r\u015fehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5844-8914","authenticated-orcid":false,"given":"Deniz Ta\u015ftemir","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Faculty of Medicine Ad\u0131yaman University Ad\u0131yaman Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization. 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