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In the present work, the molecular hybridization technique was utilized to design and synthesize nicotinic hydrazide\u20101,3,5\u2010triazine hybrids. Accordingly, this study aimed to design, perform\n                    <jats:italic>in silico<\/jats:italic>\n                    screening, synthesize, and evaluate the in vitro and in vivo anti\u2010AD potential of the proposed compounds. Docking studies revealed that the compounds displayed key interactions with catalytic site and peripheral anionic site residues. Based on binding affinity, ten compounds were synthesized and characterized using different spectroscopic techniques. In vitro AChE and BChE inhibitory assays revealed that the compound\n                    <jats:bold>4A36<\/jats:bold>\n                    showed the highest inhibitory ability with log IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 5.97\u2009\u03bcM against AChE and 4.57\u2009\u03bcM against BChE. In addition, cytotoxicity screening revealed that\n                    <jats:bold>4A36<\/jats:bold>\n                    was non\u2010toxic in SH\u2010SY5Y neuroblastoma cells in the concentration range of 15.625\u2212250\u2009\u00b5g\/mL. Acute oral toxicity evaluation of the compound revealed no adverse effects up to 175\u2009mg\/kg b.w. Further, in vivo studies using the scopolamine\u2010induced model further validated the therapeutic promise of the compound. At a dose of 30\u2009mg\/kg b.w., the compound demonstrated significant improvements in learning and memory, reduced MDA levels with concurrent elevation of antioxidant enzymes SOD and Catalase, and reduced AChE activity in hippocampal tissue. Histopathological observations revealed that treatment groups, especially at higher dose (30\u2009mg\/kg b.w.), preserved the granular layer of the dentate gyrus and improved neuronal integrity compared to the disease control. These findings indicate that\n                    <jats:bold>4A36<\/jats:bold>\n                    at a dose of 30\u2009mg\/kg b.w. may be considered as a promising lead compound in AD.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70685","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:36:59Z","timestamp":1768293419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microwave\u2010Assisted Synthesis and In Vitro Anti\u2010Alzheimer Evaluation of Novel 1,3,5\u2010Triazine\u2010Nicotinic Hydrazide Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitors"],"prefix":"10.1002","volume":"40","author":[{"given":"Tutumoni","family":"Kalita","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Dibrugarh University Dibrugarh Assam India"},{"name":"School of Pharmaceutical Sciences Girijananda Chowdhury University, Hatkhowapara, Azara Guwahati Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8232-4476","authenticated-orcid":false,"given":"Anshul","family":"Shakya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Dibrugarh University Dibrugarh Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surajit Kumar","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Dibrugarh University Dibrugarh Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udaya Pratap","family":"Singh","sequence":"additional","affiliation":[{"name":"Drug Design and Discovery Laboratory, Department of Pharmaceutical Sciences Sam Higginbottom University of Agriculture Technology and Sciences Prayagraj India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9643-4916","authenticated-orcid":false,"given":"Hans Raj","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Dibrugarh University Dibrugarh Assam India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BMC.2019.115190"},{"key":"e_1_2_12_3_1","unstructured":"Alzheimer's Disease International. 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