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A total of 36 rats were randomly divided into six groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096). Nephrotoxicity was induced by a single intraperitoneal (i.p.) injection of CIS (10\u2009mg\/kg) on day 1 in the experimental groups. OXY was administered orally at doses of 5, 10, and 20\u2009mg\/kg for three consecutive days in the treatment groups. Kidney function tests, oxidative stress markers, and molecular parameters were evaluated. Molecular analysis revealed a significant upregulation of mRNA expression of ER stress\u2010mediated markers associated with increased NLRP3 inflammasome activity in renal tissue following CIS induced toxicity. Furthermore, oxidative stress was determined with significantly decreased SOD activity and GSH levels and increased MDA levels with cisplatin administration. It has been shown that OXY administration at increasing doses causes a decrease in serum urea and creatinine levels and changes in oxidative stress parameters, and also it was shown to cause a decrease in molecular parameters of ER stress. New findings have revealed that ER stress\u2010mediated NLRP3 activation is induced in the kidneys due to cisplatin toxicity and that OXY, a potent antioxidant, may be effective through the pathways that are specified in cisplatin nephrotoxicity.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70689","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:38:31Z","timestamp":1767850711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxyresveratrol Protects Against Cisplatin Nephrotoxicity in Rats Through TXNIP\u2010Mediated NLRP3\/Caspase\u20101\/IL\u20101\u03b2 Pathway: Regulating Endoplasmic Reticulum Stress"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9173-6571","authenticated-orcid":false,"given":"Nagihan","family":"Demirtas","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy Atat\u00fcrk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6854-6059","authenticated-orcid":false,"given":"Zekai","family":"Halici","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine Atat\u00fcrk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-2365","authenticated-orcid":false,"given":"Elham Bahador","family":"Zirh","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine TOBB University of Economics and Technology Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6239-6114","authenticated-orcid":false,"given":"Saziye Sezin","family":"Palabiyik\u2010Yucelik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy Atat\u00fcrk University Erzurum Turkey"},{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy Ondokuz May\u0131s University Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0578"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33588"},{"key":"e_1_2_8_4_1","unstructured":"International Agency for Research on Cancer (IARC). 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