{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:25:03Z","timestamp":1777868703229,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic kidney injury is a cosmopolitan concern of health as it is related to high morbidity and mortality. The current study was a preclinical investigation that used a rat model to study the renal protective effect of sodium molybdate (SM) against folic acid (FA)\u2010induced nephropathy. Chronic kidney disease (CKD) was induced in rats by a single intraperitoneal (\n                    <jats:italic>i.p<\/jats:italic>\n                    .) injection of 250\u2009mg\/kg FA. SM orally administered at doses of 0.1 and 0.2\u2009g\/kg\/day for 35 days. SM attenuated FA\u2010induced chronic kidney injury that demonstrated by a significant decrease in urine total proteins\/24\u00a0h,\u00a0serum creatinine, urea concentrations, and LDH activity, and renal MDA concentration and elevation in renal TAC and GSH content. Furthermore, renal TNF\u2010\u03b1, NF\u2010\u03baB, caspase\u20103, \u03b1\u2010SMA, and hydroxyproline contents significantly reduced, meanwhile renal Bcl2 significantly increased. FA\u2010induced histopathological alterations were mitigated. SM's renoprotective effect against FA\u2010induced renal injury might be attributed to its free radical scavenger, anti\u2010inflammatory, antiapoptotic, and\/or antifibrotic mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70693","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:32:58Z","timestamp":1768293178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Protective Effect of Sodium Molybdate on Folic Acid\u2010Induced Chronic Kidney Injury in Rat Model: A Preclinical Investigation"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9763-6053","authenticated-orcid":false,"given":"Lamiaa M.","family":"Ramadan","sequence":"first","affiliation":[{"name":"Biochemistry Department National Research Centre Cairo 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