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Wistar albino rats were randomly divided into five experimental groups: Control, 0.44\u2009+\u20095.55\u2009mg\/kg Cd+As, 100\u2009mg\/kg CUR, 100 CUR + Cd+As, and 200 CUR + Cd+As groups. The Cd+As increased malondialdehyde levels and oxidative stress. However, it also led to a decrease in levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) in lung tissue homogenates. Different doses of CUR effectively prevented Cd+As\u2010induced lipid peroxidation and suppression of antioxidant capacity in lung tissue. Also, lung tissue administered Cd+As showed elevated levels of congestion, inflammation, alveolar damage, and apoptosis, as evidenced by decreased Bcl\u20102 and increased expression levels of Bax and caspase\u20103. The high dose remarkably improved lung injury in Cd+As\u2010injected rats, better than the low dose. The results show that CUR treatment is effective in protecting against Cd+As\u2010induced lipid peroxidation and reducing the negative effects of metal mixture on antioxidant status. This study suggests that CUR may be a potential new approach for the prevention\/treatment of Cd+As\u2010induced pulmonary toxicity and possibly other lung diseases associated with oxidative stress and inflammation. Furthermore, in silico studies on how CUR and Cd+As treatments affect the activities of the enzymes CAT and GPx1 showed that ROS induced by Cd+As treatment caused changes in the enzymes CAT and GPx1, while CAT was modulated by CUR treatment, whereas GPx1 was not modulated.<\/jats:p>","DOI":"10.1002\/jbt.70707","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T13:22:44Z","timestamp":1769433764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Curcumin Protects against Arsenic and Cadmium\u2010Induced Lung Toxicity in Rats by Modulating Bax\/Bcl\u20102\/caspase\u20103 Pathway: In Vivo and In Silico Approaches"],"prefix":"10.1002","volume":"40","author":[{"given":"\u0130lknur","family":"Kulcanay \u015eahin","sequence":"first","affiliation":[{"name":"Vocational School of Health Services K\u0131r\u0131kkale University K\u0131r\u0131kkale T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-6354","authenticated-orcid":false,"given":"Bahri","family":"G\u00fcr","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Sciences and Arts, I\u011fd\u0131r University I\u011fd\u0131r T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6925-8371","authenticated-orcid":false,"given":"Mustafa","family":"Cengiz","sequence":"additional","affiliation":[{"name":"Department of Elementary Education Faculty of Education, Siirt University Siirt T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0131fat","family":"Ertekin","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Eski\u015fehir Osmangazi University Eski\u015fehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3792-5993","authenticated-orcid":false,"given":"Canan","family":"Vejselova Sezer","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Arts and Sciences K\u00fctahya Dumlup\u0131nar University K\u00fctahya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7967-2245","authenticated-orcid":false,"given":"Alpaslan","family":"Bayrakdar","sequence":"additional","affiliation":[{"name":"Vocational School of Higher Education for Healthcare Services I\u011fd\u0131r University I\u011fd\u0131r T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-6090","authenticated-orcid":false,"given":"Suzan","family":"Onur","sequence":"additional","affiliation":[{"name":"Faculty of Health Science Karab\u00fck University Karab\u00fck T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Ayhanci","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Eski\u015fehir Osmangazi University Eski\u015fehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23624"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2016.04.011"},{"issue":"1","key":"e_1_2_9_4_1","article-title":"Biomedical Implications of Heavy Metals Induced Imbalances in Redox Systems","volume":"2014","author":"Sharma B.","year":"2014","journal-title":"BioMed Research International"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.7.16250"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2023.104218"},{"issue":"4","key":"e_1_2_9_7_1","first-page":"501","article-title":"Heavy Metal Induced Oxidative Stress & Its Possible Reversal by Chelation Therapy","volume":"128","author":"Flora S. 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