{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:57:02Z","timestamp":1791219422468,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chrysin (CHR), 5,7\u2010dihydroxyflavone, is a natural flavonoid found in many plant extracts possessing multiple medicinal effects, including anti\u2010inflammatory and antioxidant properties. The aim of this study was to verify the protective role of CHR on testicular and hepatic injury induced by cadmium (Cd). Adult male Sprague Dawley rats were given CdCl\n                    <jats:sub>2<\/jats:sub>\n                    (3\u2009mg\/kg, ip) for 5 days and CHR effect was evaluated using two doses (75 and 150\u2009mg\/kg\/orally). Administration of CHR showed ameliorative effects against both testicular and hepatic injury. It increased sperm quality and testosterone levels, in addition to the improvement of the integrity of blood\u2010testes barrier by decreasing Cathepsin\u2010D and increasing the regenerated potentials of SDF\u20101. Moreover, administration of CHR significantly increased SOD activity and GSH contents as well as decreased lipid peroxidation (MDA) and attenuated NOx and MPO levels in both hepatic and testicular tissues. In addition, CHR significantly mitigated Cd\u2010induced increase in pro\u2010inflammatory transcriptional factor NF\u2010\u03baB, the inflammasome pathway NLRP3\/IL\u20101\u03b2, ER stress (IRE\u20101) and caspase\u20103 apoptotic marker in both liver and testes. In conclusion, the results of this study specify that testicular and liver damage related to Cd toxicity could be improved by CHR administration.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70733","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:50:26Z","timestamp":1770238226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modulatory Effects of Chrysin on Cadmium\u2010Induced Hepatotoxicity and Testicular Injury in Rats"],"prefix":"10.1002","volume":"40","author":[{"given":"Naeimah S.","family":"Sulayman Aboulqassim","sequence":"first","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Faculty of Pharmacy, Mansoura University Mansoura Egypt"},{"name":"Department of Pharmacology &amp;Toxicology faculty of pharmacy Derna university Derna Libya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara H.","family":"Hazem","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Faculty of Pharmacy, Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-2605","authenticated-orcid":false,"given":"Maha H.","family":"Sharawy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Faculty of Pharmacy, Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3283-9471","authenticated-orcid":false,"given":"Ghada M.","family":"Suddek","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology Faculty of Pharmacy, Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","first-page":"135","article-title":"Cadmium Toxicity and Treatment: An Update","volume":"8","author":"Rafati Rahimzadeh M.","year":"2017","journal-title":"Caspian Journal of Internal Medicine"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2014.09.042"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13010036"},{"key":"e_1_2_12_5_1","unstructured":"UNEP. 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