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In this study, we established a robust aging model by synergistically combining\n                    <jats:sc>d<\/jats:sc>\n                    \u2010galactose and acute gamma\u2010irradiation (6\u2009Gy), intensified senescence\u2010associated phenotypes in rat brain tissue. Rats were divided into four groups: Group I: negative control; group II (naringin\u2010treated): rats were given naringin (50\u2009mg\/kg; p.o.) for 1 week; group III (Rad+\n                    <jats:sc>D<\/jats:sc>\n                    \u2010galactose): rats were exposed to whole\u2010body gamma radiation (6\u2009Gy) and then received\n                    <jats:sc>D<\/jats:sc>\n                    \u2010galactose (300\u2009mg\/kg b. wt. i.p.) for 7 days; group IV (Rad+\n                    <jats:sc>D<\/jats:sc>\n                    \u2010galactose+ naringin): as in group III, then naringin (50\u2009mg\/kg b. wt. p.o.) for 1 week. This model exhibited elevated levels in IL\u20106, TNF\u2010\u03b1, p16\n                    <jats:sup>INK4A<\/jats:sup>\n                    , p21\n                    <jats:sup>CIP1<\/jats:sup>\n                    and retinoblastoma protein (Rb) levels, as well as upregulated NF\u2010\u03baBp65 protein expression in brain tissue. Remarkably, naringin supplementation reversed the pathological signatures, restoring antioxidant balance, suppressing inflammatory mediators, and modulating apoptotic pathways. Histological hallmarks such as gliosis, neurophagia, and pyknosis, as well as immunohistological staining of caspase\u20103 and p53 expression, confirmed the aforementioned consequences. Collectively, these findings highlight naringin's therapeutic potential in mitigating brain aging by targeting oxidative stress, inflammation, and apoptosis. This study offers a robust experimental framework for investigating senescence and supports naringin as a promising candidate for intervention in age\u2010related neurodegenerative disorders.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70736","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T16:26:45Z","timestamp":1770395205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Naringin Mitigates Synergistic Brain Aging Model Induced by D\u2010Galactose and Gamma Radiation via Targeting Oxidative Stress, Inflammation and Senescence"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9719-3878","authenticated-orcid":false,"given":"Mahmoud E.","family":"Habieb","sequence":"first","affiliation":[{"name":"Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT) Egyptian Atomic Energy Authority (EAEA) 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Department, National Center for Radiation Research and Technology (NCRRT) Egyptian Atomic Energy Authority (EAEA) Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.05.011"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3126\/ajps.v2i1.51096"},{"key":"e_1_2_11_4_1","first-page":"1","article-title":"Cells of the Nervous System","author":"Knott G.","year":"2001","journal-title":"Encyclopedia of Life 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