{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:12:44Z","timestamp":1776942764563,"version":"3.51.4"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chrysin (CHR), a naturally occurring flavone recognized for its anti\u2010inflammatory and antioxidant activities, exhibits medicinal properties; nevertheless, the clinical use is constrained by inadequate absorption and limited bioavailability. This research employed poly\u2010lactic\u2010co\u2010glycolic acid (PLGA) as a nanodrug carrier to enhance the bioavailability, solubility, and effectiveness of CHR in protecting mice against lipopolysaccharide (LPS)\u2010acute liver and kidney damage. CHR\u2010loaded PLGA nanoparticles (CHR\u2010NPs) were synthesized and analyzed. Mice were allocated into six groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098\/group): control, LPS, Dexa (5\u2009mg\/kg), PLGA (50\u2009mg\/kg), CHR (50\u2009mg\/kg), and CHR\u2010NP (50\u2009mg\/kg). CHR\u2010NP improved liver and kidney function, alleviated histopathological abnormalities, and elevated enzymatic and non\u2010enzymatic antioxidants while reducing iron deposition, lipid peroxidation, and proinflammatory mediators. Furthermore, the Keap1\/Nrf2\/HO\u20101 signaling pathway was upregulated after oral administration of CHR\u2010NP. Through activating the Keap1\/Nrf2\/HO\u20101 signaling pathways, our data demonstrate that CHR\u2010NP significantly alleviated acute liver and kidney injury by inhibiting oxidative stress and inflammation.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70741","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:32:27Z","timestamp":1771234347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mitigating Lipopolysaccharide\u2010Induced Hepatorenal Injury: The Role of Chrysin\u2010Loaded Poly (Lactic\u2010Co\u2010Glycolic Acid) Nanoparticle in Modulating Oxidative Stress and Inflammation"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3836-4098","authenticated-orcid":false,"given":"Islam Ahmed","family":"Abdelmawgood","sequence":"first","affiliation":[{"name":"Zoology Department Faculty of Science Cairo University Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa Elsayed","family":"Abdelkader","sequence":"additional","affiliation":[{"name":"Zoology Department Faculty of Science Cairo University Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha A.","family":"Mahana","sequence":"additional","affiliation":[{"name":"Zoology Department Faculty of Science Cairo University Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel Hady A.","family":"Abdel Wahab","sequence":"additional","affiliation":[{"name":"Cancer Biology Department National Cancer Institute Cairo University Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3503-6639","authenticated-orcid":false,"given":"Abeer Mahmoud","family":"Badr","sequence":"additional","affiliation":[{"name":"Zoology Department Faculty of Science Cairo University Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3975-4355","authenticated-orcid":false,"given":"Ayman Saber","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Zoology Department Faculty of Science Cairo University Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"issue":"8","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis\u20103)","volume":"315","author":"Singer M.","year":"2016","journal-title":"Journal of the American Medical Association (Chicago, IL)"},{"issue":"10141","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and Septic Shock","volume":"392","author":"Cecconi M.","year":"2018","journal-title":"Lancet"},{"issue":"2","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00210-023-02650-y","article-title":"Modulating Nrf\u20102\/HO\u20101, Apoptosis and Oxidative Stress Signaling Pathways by Gabapentin Ameliorates Sepsis\u2010Induced Acute Kidney Injury","volume":"397","author":"Abdelnaser M.","year":"2024","journal-title":"Naunyn\u2010Schmiedeberg's Archives of Pharmacology"},{"issue":"3","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1080\/10799893.2020.1808675","article-title":"Irisin Alleviates LPS\u2010Induced Liver Injury and Inflammation Through Inhibition of NLRP3 Inflammasome and NF\u2010\u03baB Signaling","volume":"41","author":"Li Q.","year":"2021","journal-title":"Journal of Receptors and Signal Transduction"},{"issue":"6","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/CCM.0000000000003023","article-title":"The Impact of Acute Organ Dysfunction on Long\u2010Term Survival in Sepsis*","volume":"46","author":"Schuler A.","year":"2018","journal-title":"Critical Care Medicine"},{"issue":"6","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s00134-017-4755-7","article-title":"Acute Kidney Injury in Sepsis","volume":"43","author":"Bellomo R.","year":"2017","journal-title":"Intensive Care Medicine"},{"issue":"2","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ccc.2020.11.010","article-title":"Sepsis\u2010Associated Acute Kidney Injury","volume":"37","author":"Manrique\u2010Caballero C. 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Corticosteroids in Sepsis and Septic Shock: A Systematic Review, Pairwise, and Dose\u2010Response Meta\u2010Analysis","volume":"6","author":"Pitre T.","journal-title":"Crit Care Explor 2024"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2025.104470","article-title":"Protective Effect of Isopimpinellin on Ovalbumin\u2010Induced Airway Inflammation and Oxidative Stress in Mouse Model of Asthma","volume":"337","author":"Abdelmawgood I. A.","year":"2025","journal-title":"Respiratory Physiology & Neurobiology"},{"issue":"9","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.freeradbiomed.2009.07.035","article-title":"Nrf2:INrf2 (Keap1) Signaling in Oxidative Stress","volume":"47","author":"Kaspar J. 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