{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:44:29Z","timestamp":1791287069391,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study was conducted to examine whether bleomycin\u2010induced growth inhibitory action on rat insulinoma cells (RIN5F)\n                    <jats:italic>in vitro<\/jats:italic>\n                    and hyperglycemia in female Wistar rats is influenced by arachidonic acid (AA) and its anti\u2010inflammatory metabolite: lipoxin A4 (LXA4). The\n                    <jats:italic>in vitro<\/jats:italic>\n                    study was conducted using RIN5F cells. The potential of various PUFAs (polyunsaturated fatty acids), eicosanoids and LXA4, resolvin D1 and protectin D1 to modify the growth inhibitory effects of bleomycin was measured by MTT assay. In an\n                    <jats:italic>in vivo<\/jats:italic>\n                    study, we tested the effect of AA and LXA4 on bleomycin\u2010induced hyperglycemia in female Wistar rats. We noted that of all the PUFAs and their metabolites tested, AA (10\u2009\u00b5g\/mL) and LXA4 (1\u2009ng\/mL) are the most effective in protecting RIN5F cells against bleomycin induced growth suppression. An increase in LXA4 levels was noted when RIN5F cells were supplemented with AA. Bleomycin induced a significant increase in the fasting blood glucose levels and decreased plasma insulin levels that were reverted to normal by LXA4 (50\u2009ng\/animal). AA (50\u2009\u03bcg\/animal) and LXA4 improved the antioxidant status and upregulated anti\u2010inflammatory and anti\u2010apoptotic genes I\u03baB and Bcl2. These results suggest AA and LXA4 can prevent bleomycin\u2010induced dysfunction of pancreatic \u03b2 cells.\n                  <\/jats:p>","DOI":"10.1002\/jbt.70745","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T06:36:53Z","timestamp":1771828613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Arachidonic Acid and Lipoxin A4 Protect Pancreatic \u03b2\u2010Cells and Improve Hyperglycemia Induced by Bleomycin"],"prefix":"10.1002","volume":"40","author":[{"given":"Sailaja","family":"Polavarapu","sequence":"first","affiliation":[{"name":"BioScience Research Centre GVP Engineering College Visakhapatnam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorani","family":"Rhenghachar","sequence":"additional","affiliation":[{"name":"BioScience Research Centre GVP Engineering College Visakhapatnam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0191-9508","authenticated-orcid":false,"given":"Undurti N.","family":"Das","sequence":"additional","affiliation":[{"name":"BioScience Research Centre GVP Engineering College Visakhapatnam India"},{"name":"UND Life Sciences Battle Ground Washington USA"},{"name":"Department of Biotechnology Indian Institute of Technology\u2010Hyderabad Sangareddy India"},{"name":"Department of Medicine Omega Hospitals, Gachibowli Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"292","article-title":"The Effect of Chemical Therapy With Bleomycin Sulfate on the Functional Parameters of the Endocrine Pancreas","volume":"18","author":"Silva C. 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