{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:13:30Z","timestamp":1778649210675,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Hepatocellular carcinoma (HCC) is the 5th rank among all types of cancers, the incidence of the HCC increases globally. The current study was scrutinized the chemoprotective effect of nimbolide against dimethylnitrosamine (DEN) induced HCC in rats via alteration of PI3K\/Akt\/mTOR signaling pathways. Intraperitoneal administration of DEN (200\u2009mg\/kg) was used for the induction of HCC in the rats and rats were received the oral administration of nimbolide (10, 20, and 40\u2009mg\/kg). The body weight, liver weight, liver index, electrolyte, membrane bound enzymes, antioxidant, inflammatory cytokines, inflammatory parameters and apoptosis parameters were estimated. The mRNA expressions were estimated in the hepatic tissue. Nimbolide treatment improved the body weight and diminished the liver weight and liver index. Nimbolide treatment altered the electrolyte (sodium, potassium, calcium, magnesium), membrane bound enzymes, antioxidant parameters cytokines (tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin\u20101\u03b2 (IL\u20101\u03b2), interleukin\u20102 (IL\u20102), interleukin\u20106 (IL\u20106), interleukin\u20107 (IL\u20107), interleukin\u201010 (IL\u201010), interleukin\u201017 (IL\u201017), interleukin\u201018 (IL\u201018)), inflammatory parameters (cyclooxygenase\u20102 (COX\u20102), prostaglandin (PGE2), inducible nitric oxide synthetase (iNOS), nuclear factor kappa B (NF\u2010\u03baB), vascular endothelial growth factor (VEGF)), apoptosis parameters such as B\u2010cell lymphoma 2 (Bcl\u20102), Bcl\u20102\u2010associated X protein (Bax), Bcl\u20102:Bax ratio, cysteine\u2010aspartic acid protease\u20103 (caspase\u20103) and C\u2010reactive protein (CRP) level. Nimbolide treatment significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) altered the mRNA expression of tumor protein p53 (p53), Bax, Mechanistic target of rapamycin (mTOR), Bcl\u20102, Cysteine\u2010aspartic acid protease\u20109 (caspase\u20109), caspase\u20103, phosphoinositide 3\u2010kinase (PI3K), IQ motif\u2013containing GTPase\u2010activating protein 1 (IQGAP1), Protein kinase B (PKB) (AKT), IQ motif\u2013containing GTPase\u2010activating protein 2 (IQGAP2), IQ motif\u2013containing GTPase\u2010activating protein 3 (IQGAP3), Kirsten rat sarcoma viral oncogene homolog (KRAS) and Harvey rat sarcoma viral oncogene homolog (HRAS). The result clearly showed the chemoprotective effect of nimbolide against DEN induced HCC in rats via alteration of PI3K\/Akt\/mTOR signaling pathways.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbt.70767","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:49:08Z","timestamp":1778647748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemoprotective of Nimbolide Against Diethylnitrosamine Induced Hepatic Cancer via Alteration of NF\u2010\u03baB and PI3K\/Akt\/mTOR Signaling Pathways"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7201-8837","authenticated-orcid":false,"given":"Simiao","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine Hunan University of Traditional Chinese Medicine Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Ningbo Yinzhou No.2 Hospital Ningbo Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqi","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of General Practice General Hospital of the Western Theater Command of Chinese People's Liberation Army Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianjing","family":"Zeng","sequence":"additional","affiliation":[{"name":"General Practice Medicine, Affiliated Hospital of Jinggangshan University Ji'an Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhong","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Affiliated Hospital of Jinggangshan University Ji'an Jiangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1","article-title":"Hepatocellular Carcinoma (HCC): Epidemiology, Etiology and Molecular Classification","volume":"149","author":"Chidambaranathan\u2010Reghupaty S.","year":"2021","journal-title":"Advances in Cancer Research"},{"issue":"4","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.5650\/jos.ess21415","article-title":"Daphnetin Ameliorates the Expansion of Chemically Induced Hepatocellular Carcinoma via Reduction of Inflammation and Oxidative Stress","volume":"71","author":"Li T.","year":"2022","journal-title":"Journal of Oleo Science"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1080\/17425247.2021.1860939","article-title":"Current Status and Future Directions of Hepatocellular Carcinoma\u2010Targeted Nanoparticles and Nanomedicine","volume":"18","author":"Kumar V.","year":"2021","journal-title":"Expert Opinion on Drug Delivery"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/17425247.2021.1854223","article-title":"Nanocarriers\u2010Loaded With Natural Actives as Newer Therapeutic Interventions for Treatment of Hepatocellular Carcinoma","volume":"18","author":"Rahman M.","year":"2021","journal-title":"Expert Opinion on Drug Delivery"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1111\/liv.15130","article-title":"Treatment and the Prognosis of Hepatocellular Carcinoma in Asia","volume":"42","author":"Torimura T.","year":"2022","journal-title":"Liver International"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-981-19-0120-1_15","volume-title":"Sex\/Gender\u2010Specific Medicine in the Gastrointestinal Diseases","author":"Kim W.","year":"2022"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3350\/cmh.2023.0125","article-title":"Recent Advances in the Management of Hepatocellular Carcinoma","volume":"30","author":"Sankar K.","year":"2023","journal-title":"Clinical and Molecular Hepatology"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","article-title":"Hepatocellular Carcinoma","volume":"400","author":"Vogel A.","year":"2022","journal-title":"Lancet"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular Carcinoma","volume":"7","author":"Llovet J. M.","year":"2021","journal-title":"Nature Reviews Disease Primers"},{"issue":"7","key":"e_1_2_10_11_1","first-page":"1643","article-title":"Chemopreventive Effect of Baicalin Against Diethylnitrosamine Induced Hepatocellular Carcinoma via Inhibition of Angiogenesis, Hypoxia and Metastatic Markers","volume":"40","author":"Cheng M.","year":"2021","journal-title":"Latin American Journal of Pharmacy"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.2147\/JIR.S330499","article-title":"Curcumae Ameliorates Diethylnitrosamine\u2010Induced Hepatocellular Carcinoma via Alteration of Oxidative Stress, Inflammation and Gut Microbiota","volume":"14","author":"Zhang Y.","year":"2021","journal-title":"Journal of Inflammation Research"},{"issue":"6","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/fcp.13032","article-title":"Acetazolamide Suppresses the Progression of Hepatocellular Carcinoma Induced by Diethylnitrosamine in Wistar Albino Rats","volume":"38","author":"Tamim Y. M.","year":"2024","journal-title":"Fundamental & Clinical Pharmacology"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrep.2025.102297","article-title":"Caffeine Improves Diethylnitrosamine\u2010Induced Hepatocellular Carcinoma by Inhibiting cAMP\/PKA\/CREB Signaling in Rats","volume":"44","author":"Shan L.","year":"2025","journal-title":"Biochemistry and Biophysics Reports"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.12688\/f1000research.145961.2","article-title":"Kadukkai Maathirai (Indian Herbal Drug) Prevents Hepatocellular Cancer Progression by Enhancing GSTM1 Expression and Modulating \u03b2 Catenin Transcription: In\u2010Silico and In\u2010Vivo Study","volume":"13","author":"Shetty M.","year":"2024","journal-title":"F1000Research"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/09603271231165664"},{"issue":"4","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1097\/HEP.0000000000001037","article-title":"Genomic and Transcriptomic Analyses of Chemical Hepatocarcinogenesis Aggravated by Oncoprotein Loss","volume":"81","author":"Wang X.","year":"2025","journal-title":"Hepatology"},{"issue":"1","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"8013","DOI":"10.1038\/s41598-024-58587-6","article-title":"Proteomic Analysis of DEN and CCl4\u2010Induced Hepatocellular Carcinoma Mouse Model","volume":"14","author":"Zhang Q.","year":"2024","journal-title":"Scientific Reports"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v31.i26.106113","article-title":"Chinese Medicine Monomers for Hepatocellular Carcinoma: New Ideas Related to Autophagy","volume":"31","author":"Zheng S. H.","year":"2025","journal-title":"World Journal of Gastroenterology"},{"issue":"3","key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2174\/0113894501312571240920070441","article-title":"A Review on Nanotechnologically Derived Phytomedicines for the Treatment of Hepatocellular Carcinoma: Recent Advances in Molecular Mechanism and Drug Targeting","volume":"26","author":"Sahu C.","year":"2025","journal-title":"Current Drug Targets"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.2147\/IJN.S136629","article-title":"Fabrication, Optimization, and Characterization of Umbelliferone \u03b2\u2010D\u2010galactopyranoside\u2010loaded PLGA Nanoparticles in Treatment of Hepatocellular Carcinoma: In Vitro and In Vivo Studies","volume":"12","author":"Kumar V.","year":"2017","journal-title":"International Journal of Nanomedicine [Internet]"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.abb.2017.05.006","article-title":"Thiamine Potentiates Chemoprotective Effects of Ibuprofen in DEN Induced Hepatic Cancer via Alteration of Oxidative Stress and Inflammatory Mechanism","volume":"623","author":"Afzal M.","year":"2017","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.2147\/IJN.S136629","article-title":"Fabrication, Optimization, and Characterization of Umbelliferone \u03b2\u2010D\u2010Galactopyranoside\u2010Loaded PLGA Nanoparticles in Treatment of Hepatocellular Carcinoma: In Vitro and In Vivo Studies","volume":"12","author":"Kumar V.","year":"2017","journal-title":"International Journal of Nanomedicine"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111335","article-title":"Phyllanthin Prevents Diethylnitrosamine (DEN) Induced Liver Carcinogenesis in Rats and Induces Apoptotic Cell Death in HepG2 Cells","volume":"137","author":"You Y.","year":"2021","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"13","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"6940","DOI":"10.1039\/C7RA12775H","article-title":"Amelioration of Diethylnitrosamine (DEN)\u2010Induced Hepatocellular Carcinogenesis in Animal Models: via Knockdown Oxidative Stress and Proinflammatory Markers by Madhuca longifolia Embedded Silver Nanoparticles","volume":"8","author":"Singh D.","year":"2018","journal-title":"RSC Advances"},{"issue":"12","key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.3390\/ph15121558","article-title":"Protective Effects of Naringin\u2013Dextrin Nanoformula Against Chemically Induced Hepatocellular Carcinoma in Wistar Rats: Roles of Oxidative Stress, Inflammation, Cell Apoptosis, and Proliferation","volume":"15","author":"Mohamed E. E.","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"8","key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1093\/nar\/gkaa115","article-title":"Deletion of Endonuclease v Suppresses Chemically Induced Hepatocellular Carcinoma","volume":"48","author":"Kong X. Y.","year":"2020","journal-title":"Nucleic Acids Research"},{"issue":"11","key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1248\/bpb.b23-00342","article-title":"Estrogen Attenuates Diethylnitrosamine\u2010Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor\/FASN\/CD36\/IL\u20106 Axis","volume":"46","author":"Abdel\u2010Hamid M. S.","year":"2023","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3389\/fphar.2020.00809","article-title":"Gehua Jiecheng Decoction Inhibits Diethylnitrosamine\u2010Induced Hepatocellular Carcinoma in Mice by Improving Tumor Immunosuppression Microenvironment","volume":"11","author":"Cheng C.","year":"2020","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.7314\/APJCP.2015.16.1.103","article-title":"Hepatoprotective Effects of Curcumin Against Diethyl Nitrosamine Induced Hepatotoxicity in Albino Rats","volume":"16","author":"Kadasa N. M.","year":"2015","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"issue":"1","key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1080\/10717544.2019.1606865","article-title":"Ganoderic Acid Loaded Nano\u2010Lipidic Carriers Improvise Treatment of Hepatocellular Carcinoma","volume":"26","author":"Rahman M.","year":"2019","journal-title":"Drug Delivery"},{"issue":"12","key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.4314\/tjpr.v19i12.23","article-title":"Effect of Ganoderic Acid on Diethylnitrosamine\u2010Induced Liver Cancer in Mice","volume":"19","author":"Sun Z.","year":"2021","journal-title":"Tropical Journal of Pharmaceutical Research"},{"issue":"5","key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1016\/j.sjbs.2022.02.012","article-title":"Anticancer Effect of Selenium\/Chitosan\/Polyethylene Glycol\/Allyl Isothiocyanate Nanocomposites Against Diethylnitrosamine\u2010Induced Liver Cancer in Rats","volume":"29","author":"Li C.","year":"2022","journal-title":"Saudi Journal of Biological Sciences"},{"issue":"1","key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10787-017-0350-3","article-title":"Triterpenoids Principle of Wedelia Calendulacea Attenuated Diethynitrosamine\u2010Induced Hepatocellular Carcinoma via Down\u2010Regulating Oxidative Stress, Inflammation and Pathology via NF\u2010kB Pathway","volume":"26","author":"Verma A.","year":"2018","journal-title":"Inflammopharmacology"},{"issue":"1","key":"e_1_2_10_35_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-16321-0","article-title":"Calotropis gigantea Stem Bark Extracts Inhibit Liver Cancer Induced by Diethylnitrosamine","volume":"12","author":"Sawong S.","year":"2022","journal-title":"Scientific Reports"},{"issue":"24","key":"e_1_2_10_36_1","first-page":"6724","article-title":"[Tanshinone \u2161_A Exerts Anti\u2010Hepatocellular Carcinoma Effects by Inhibiting Oxidative Stress via PI3K\/Akt and Nrf2\/HO\u20101 Signaling Pathway]","volume":"49","author":"Fang M.","year":"2024","journal-title":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China Journal of Chinese materia medica"},{"issue":"10440","key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/S0140-6736(24)00757-8","article-title":"Global Incidence, Prevalence, Years Lived With Disability (YLDs), Disability\u2010Adjusted Life\u2010Years (DALYs), and Healthy Life Expectancy (HALE) for 371 Diseases and Injuries in 204 Countries and Territories and 811 Subnational Locations, 1990\u20132021: A Systematic Analysis for the Global Burden of Disease Study 2021","volume":"403","author":"Ferrari A. J.","year":"2024","journal-title":"Lancet"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.114587","article-title":"Ginsenoside Rk1 Induces Autophagy\u2010Dependent Apoptosis in Hepatocellular Carcinoma by AMPK\/mTOR Signaling Pathway","volume":"186","author":"Wu H.","year":"2024","journal-title":"Food and Chemical Toxicology"},{"issue":"2","key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41417-021-00300-0","article-title":"Knockout of ASPP2 Promotes DEN\u2010Induced Hepatocarcinogenesis via the NF\u2010\u03baB Pathway in Mice","volume":"29","author":"Wang S.","year":"2022","journal-title":"Cancer Gene Therapy"},{"issue":"2","key":"e_1_2_10_40_1","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ad1dff","article-title":"Use of Antioxidant Nanoliposomes for Co\u2010Delivery of PTEN Plasmids and Plumbagin to Induce Apoptosis in Hepatic Cancer Cells","volume":"19","author":"Bhagat S.","year":"2024","journal-title":"Biomedical Materials"},{"issue":"3","key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1007\/s12010-022-04203-0","article-title":"Simvastatin Induces Apoptosis and Suppresses Hepatocellular Carcinoma Induced In Rats","volume":"195","author":"Elleithi Y. A.","year":"2023","journal-title":"Applied Biochemistry and Biotechnology"},{"issue":"10","key":"e_1_2_10_42_1","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1002\/mc.70021","article-title":"Monocarboxylate Transporter\u20101 Is Dispensable for Hepatocellular Carcinoma Development","volume":"64","author":"Gad S. A.","year":"2025","journal-title":"Molecular Carcinogenesis"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.920652","article-title":"Role of IQ Motif\u2010Containing GTPase\u2010Activating Proteins in Hepatocellular Carcinoma","volume":"12","author":"Dai Q.","year":"2022","journal-title":"Frontiers in Oncology"},{"issue":"8","key":"e_1_2_10_44_1","first-page":"8821","article-title":"Gene Expression of IQGAPs and Ras Families in an Experimental Mouse Model for Hepatocellular Carcinoma: A Mechanistic Study of Cancer Progression","volume":"8","author":"Zoheir K. M.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"issue":"9","key":"e_1_2_10_45_1","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.5650\/jos.ess22033","article-title":"Chemoprotective Effect of Decalactone on Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress","volume":"71","author":"Shen H.","year":"2022","journal-title":"Journal of Oleo Science"},{"key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cbi.2017.09.015","article-title":"Hesperidin Protects Against Chemically Induced Hepatocarcinogenesis via Modulation of Nrf2\/ARE\/HO\u20101, PPAR\u03b3 and TGF\u2010\u03b21\/Smad3 Signaling, and Amelioration of Oxidative Stress and Inflammation","volume":"277","author":"Mahmoud A. M.","year":"2017","journal-title":"Chemico\u2010Biological Interactions"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70767","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.70767","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.70767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:49:19Z","timestamp":1778647759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.70767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/jbt.70767"],"URL":"https:\/\/doi.org\/10.1002\/jbt.70767","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70767"}}